University of Oulu

Arvonen, M., Berntson, L., Pokka, T. et al. Gut microbiota-host interactions and juvenile idiopathic arthritis. Pediatr Rheumatol 14, 44 (2016) doi:10.1186/s12969-016-0104-6

Gut microbiota-host interactions and juvenile idiopathic arthritis

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Author: Arvonen, Miika1,2,3; Berntson, Lillemor4; Pokka, Tytti2,3,5;
Organizations: 1Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
2Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
3PEDEGO Research Unit, University of Oulu, Oulu, Finland
4Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
5Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
6Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
7Department of Pathology, Oulu University Hospital, Oulu, Finland
8Department of Pediatrics, University of Alabama at Birmingham, CPP N 210 M, 1600 7th Avenue South, Birmingham, AL, 35233, USA
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link:
Language: English
Published: Springer Nature, 2016
Publish Date: 2019-11-08


Background: Juvenile idiopathic arthritis is the most common form of chronic arthritis in children. There is mounting evidence that the microbiota may influence the disease.

Main body: Recent observations in several systemic inflammatory diseases including JIA have indicated that abnormalities in the contents of the microbiota may be factors in disease pathogenesis, while other studies in turn have shown that environmental factors impacting the composition of the microbiota, such as delivery mode and early exposure to antibiotics, affect the risk of chronic inflammatory diseases including JIA. Microbial alterations may predispose to JIA through a variety of mechanisms, including impaired immunologic development, alterations in the balances of pro- versus anti-inflammatory bacteria, and low-grade mucosal inflammation. Additional confirmatory studies of microbiota aberrations and their risk factors are needed, as well as additional mechanistic studies linking these alterations to the disease itself.

Conclusions: The microbiota may influence the risk of JIA and other systemic inflammatory conditions through a variety of mechanisms. Additional research is required to improve our understanding of the links between the microbiota and arthritis, and the treatment implications thereof.

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Series: Pediatric rheumatology
ISSN: 1546-0096
ISSN-E: 1546-0096
ISSN-L: 1546-0096
Volume: 14
Article number: 44
DOI: 10.1186/s12969-016-0104-6
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Copyright information: © The Authors 2016.This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.