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Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women |
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| Author: | Liuhanen, Johanna1; Suvisaari, Jaana1; Kajantie, Eero1,2,3; |
| Organizations: |
1National Institute for Health and Welfare, Helsinki, Finland 2Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland 3Department of Obstetrics and Gynaecology, Oulu University Central Hospital and University of Oulu, Oulu, Finland
4Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
5Department of Psychiatry, Oulu University Hospital, Oulu, Finland 6Institute for Molecular Medicine Finland, Helsinki, Finland 7Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom 8Biocenter Oulu, University of Oulu, Oulu, Finland 9Institute of Health Sciences, University of Oulu, Oulu, Finland 10Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland 11Unit of Primary Care, Oulu University Hospital, Oulu, Finland 12Department of Psychiatry, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019111137506 |
| Language: | English |
| Published: |
Elsevier,
2018
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| Publish Date: | 2019-11-11 |
| Description: |
AbstractSchizophrenia is a highly heritable disease, but despite extensive study, its genetic background remains unresolved. The lack of environmental measures in genetic studies may offer some explanation. In recent Finnish studies, high birth weight was found to increase the risk for familial schizophrenia. We examined the interaction between a polygenic risk score for schizophrenia and high birth weight on social anhedonia and schizophrenia in a general population birth cohort. The study sample included 4223 participants from the 1966 Northern Finland Birth Cohort. As a replication sample we used 256 participants from a systematically collected sample of Finnish schizophrenia families. The polygenic risk score comprised of variants published in the large genome-wide meta-analysis for schizophrenia. We found the association between the polygenic risk score and social anhedonia stronger among those with high birth weight, and the same phenomenon was seen for schizophrenia among women, suggesting a gene-environment interaction. Similar results were found within the replication sample. Our results suggest a role for gene-environment interactions in assessing the risk of schizophrenia. Failure to take environmental effects into account may be one of the reasons why identifying significant SNPs for schizophrenia in genome-wide studies has been challenging. see all
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| Series: |
Psychiatry research |
| ISSN: | 0165-1781 |
| ISSN-E: | 1872-7123 |
| ISSN-L: | 0165-1781 |
| Volume: | 259 |
| Pages: | 148 - 153 |
| DOI: | 10.1016/j.psychres.2017.10.020 |
| OADOI: | https://oadoi.org/10.1016/j.psychres.2017.10.020 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
JLi was supported by the Sigrid Juselius Foundation (work group grant/Jouko Lönnqvist). JM was supported by grants from the Academy of Finland (project grant 268336), the Jalmari and Rauha Ahokas Foundation, and the Northern Finland Health Care Support Foundation. EK was supported by grants from the Academy of Finland, Finnish Foundation for pediatric research, Emil Aaltonen Foundation, Sigrid Juselius Foundation, and Novo Nordisk Foundation. NFBC1966 received financial support from the Academy of Finland (project grants 104781, 120315, 129269, 1114194, 24300796, Center of Excellence in Complex Disease Genetics and SALVE), University Hospital Oulu, Biocenter, University of Oulu, Finland (75617), NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), NIH/NIMH (5R01MH63706:02), ENGAGE project and grant agreement HEALTH-F4-2007-201413, EU FP7 EurHEALTHAgeing − 277849 and the Medical Research Council, UK (G0500539, G0600705, G1002319, PrevMetSyn/SALVE). The Schizophrenia family sample received financial support from the Sigrid Juselius Foundation. The DNA extractions, sample quality controls, biobank up-keeping and aliquotting was performed in the National Public Health Institute, Biomedicum Helsinki, Finland and supported financially by the Academy of Finland and Biocentrum Helsinki. We thank the late Professor Paula Rantakallio (launch of NFBC1966), and Ms Outi Tornwall and Ms Minttu Jussila (DNA biobanking). |
| EU Grant Number: |
(277849) EURHEALTHAGEING - European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing |
| Academy of Finland Grant Number: |
120315 129269 268336 114194 |
| Detailed Information: |
120315 (Academy of Finland Funding decision) 129269 (Academy of Finland Funding decision) 268336 (Academy of Finland Funding decision) 114194 (Academy of Finland Funding decision) |
| Copyright information: |
© 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. |