University of Oulu

Girchenko, P., Lahti-Pulkkinen, M., Lahti, J. et al. Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity: findings from the prospective PREDO Study. Pediatr Res 84, 875–881 (2018) doi:10.1038/s41390-018-0199-1

Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity : findings from the prospective PREDO Study

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Author: Girchenko, Polina1; Lahti-Pulkkinen, Marius1; Lahti, Jari1;
Organizations: 1Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
2HUSLAB and Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
3Obstetrics and Gynaecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
4National Institute for Health and Welfare, Helsinki and Oulu, Helsinki, Finland
5Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Endocrinology Unit, Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 4.2 MB)
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Language: English
Published: Springer Nature, 2018
Publish Date: 2019-11-12


Introduction: Maternal overweight/obesity and comorbid hypertensive disorders and gestational diabetes associate with neurodevelopmental delay in the offspring in childhood. We hypothesize that these maternal conditions associate also with the offspring regulatory behavior problems and impact on neurodevelopment via the offspring regulatory behavior.

Methods: A number of 3117 women of the PREDO Study filled in a questionnaire on regulatory behavior problems at the child’s mean age of 16.9 days and 2116 of them a questionnaire on developmental milestones at the child’s mean age of 42.2 months. Data on maternal BMI and comorbid disorders come from the Finnish Medical Birth Register.

Results: Offspring of overweight/obese mothers in comparison to normal weight mothers had higher levels of regulatory behavior problems and 22% (95% confidence interval 5–42%) higher odds of having problems on multiple domains of behavioral regulation at the mean age of 16.9 days. Offspring regulatory behavior problems partially mediated the association between maternal overweight/obesity and developmental milestones comprising communication, gross motor, fine motor, problem solving, and personal/social domains of development. Comorbid disorders did not associate with offspring regulatory behavior problems.

Conclusion: Regulatory behavior problems of the offspring have prenatal origins and partially mediate the effects of maternal overweight/obesity on offspring neurodevelopment.

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Series: Pediatric research
ISSN: 0031-3998
ISSN-E: 1530-0447
ISSN-L: 0031-3998
Volume: 84
Issue: 6
Pages: 875 - 881
DOI: 10.1038/s41390-018-0199-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: This work was supported by the Academy of Finland (K.R., grant numbers 284859, 2848591, and 312670), (E.K., grant numbers 127437, 129306, 130326, 134791, 263924, and 274794), (H.L., grant numbers 121196, 134957, and 278941), (M.L.-P., grant number 12853241), (A.-K.P.); University of Helsinki Research Funds (M.L.-P.), (H.L.), British Heart Foundation (R.M.R.); Tommy’s (R.M.R.); European Commission (E.K., K.R., Horizon 2020 Award SC1-2016-RTD-733280 RECAP); Foundation for Pediatric Research (E.K.); Juho Vainio Foundation (E.K.); Novo Nordisk Foundation (E.K.); Signe and Ane Gyllenberg Foundation (K.R., E.K.); Sigrid Jusélius Foundation (E.K.); Finnish Medical Foundation (H.L.); Jane and Aatos Erkko Foundation (H.L.); Päivikki and Sakari Sohlberg Foundation (H.L.); and Doctoral Program of Psychology, Learning, and Communication (P.G.).
Copyright information: © 2019 Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Pediatric Research. The final authenticated version is available online at: