Tuovinen, S, Lahti‐Pulkkinen, M, Girchenko, P, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018; 35: 732– 741. https://doi.org/10.1002/da.22756
Maternal depressive symptoms during and after pregnancy and child developmental milestones
|Author:||Tuovinen, Soile1; Lahti-Pulkkinen, Marius1,2,3; Girchenko, Polina1;|
1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
2University/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, UK
3National Institute for Health and Welfare, Helsinki, Finland
4Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland 5
5Department of Clinical Chemistry, Helsinki University Hospital and University of Helsinki, Finland
6Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
7PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
8Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Finland
9Institute for Molecular Medicine Finland/HiLIFE, University of Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019111237679
John Wiley & Sons,
|Publish Date:|| 2019-11-12
Background: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear.
Methods: A total of 2,231 mothers of the Prediction and Prevention of Pre‐eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy. At child’s age 1.9–5.7 years, the mothers completed the Beck Depression Inventory‐II on their concurrent depressive symptoms and Ages and Stages Questionnaire on child developmental milestones.
Results: Higher mean maternal depressive symptoms, each biweekly score, and consistently clinically relevant symptomatology during pregnancy predicted lower total developmental milestones, fine and gross motor, communication, problem solving, and personal/social skills scores in children. Although maternal depressive symptoms up to 12 months after pregnancy and in early childhood also predicted lower developmental milestones scores, developmental milestones scores were the lowest in children whose mothers’ depressive symptoms were above the clinical cutoff either only during pregnancy, both during and up to 12 months after pregnancy, or at each three time‐points.
Conclusion: Maternal depressive symptoms during pregnancy, in the first year postpartum and in early childhood are associated with poorer child neurodevelopment. Our findings further suggest that antenatal and postpregnancy depression have additive effects on neurodevelopment. Children of mothers with the most chronic and severe depressive symptoms during pregnancy had the most neurodevelopmental disadvantages. Our findings emphasize the adverse effects of maternal depression during and after pregnancy and in early childhood on child neurodevelopment.
Depression & anxiety
|Pages:||732 - 741|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
3124 Neurology and psychiatry
The PREDO study is funded by the Academy of Finland, EraNetNeuron, EVO, University of Helsinki Research Funds, and the Signe and Ane Gyllenberg, Emil Aaltonen, Jane and Aatos Erkko, Novo Nordisk, Päivikki and Sakari Sohlberg, and Sigrid Juselius Foundations, the Finnish Medical Foundation, the British Heart Foundation and the European Commission Horizon 2020 Award SC1‐2016‐RTD‐733280 RECAP.
© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Tuovinen, S, Lahti‐Pulkkinen, M, Girchenko, P, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018; 35: 732– 741. https://doi.org/10.1002/da.22756, which has been published in final form at https://doi.org/10.1002/da.22756. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.