Petteri Oura, Markus Paananen, Marja Ojaniemi, Juha Auvinen, Juho-Antti Junno, Jaro Karppinen, Jaakko Niinimäki, Effect of early life physical growth on midlife vertebral dimensions — The Northern Finland Birth Cohort 1966 study, Bone, Volume 101, 2017, Pages 172-178, ISSN 8756-3282, https://doi.org/10.1016/j.bone.2017.05.006
Effect of early life physical growth on midlife vertebral dimensions : the Northern Finland Birth Cohort 1966 study
|Author:||Oura, Petteri1,2,3; Paananen, Markus1,2; Ojaniemi, Marja4,5;|
1Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
4PEDEGO Research Unit, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
5Department of Children and Adolescents, Oulu University Hospital, P.O. Box 23, FI-90029 Oulu, Finland
6Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
7Department of Archaeology, Faculty of Humanities, University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland
8Finnish Institute of Occupational Health, Kastelli Research Center, Aapistie 1, FI-90220 Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019111237689
|Publish Date:|| 2019-11-12
Small vertebral size is an independent risk factor for osteoporotic vertebral fractures. Physical growth in early life is related to bone health in later life, but the relationship of early growth versus vertebral size has been inconclusively studied. Utilizing the Northern Finland Birth Cohort 1966 with a 47-year follow-up, we investigated how physical growth in early life is associated with midlife vertebral dimensions. We obtained several physical growth parameters of 1) birth (gestational age, length, weight, BMI), 2) infancy and childhood (peak height velocity (PHV), peak weight velocity (PWV), adiposity peak (AP), adiposity rebound (AR)), and 3) puberty (BMI at growth spurt take-off (TO), PHV, height change). We also studied 4) the ages at which AP, AR, pubertal TO and pubertal PHV occurred. The outcome variable, vertebral cross-sectional area (CSA), was obtained from magnetic resonance imaging scans at the mean age of 46.7 years (n = 517). Sex-stratified linear regression analyses were used with adjustments for gestational age, smoking, and education. Birth length/weight/BMI, and adult height/weight/BMI were also used as covariates, depending on the model. According to our results, birth weight (p ≤ 0.006) and infant PWV (p ≤ 0.001) were positively associated with midlife vertebral CSA among both sexes. Length/height variables were associated with vertebral size only before including adult height in the models, and became non-significant thereafter. Among women, BMIs at birth, AP, AR, and pubertal TO were positively associated with midlife vertebral CSA (p < 0.05), whereas among men, only high BMI at AR was associated with large vertebral size (p = 0.028). Gestational age and timing of growth were not associated with future vertebral CSA. We conclude that early life weight gain is positively associated with midlife vertebral CSA, and suggest that adult height may mediate the effect of height gain on vertebral size.
|Pages:||172 - 178|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
NFBC1966 received financial support from the Academy of Finland; Oulu University Hospital; University of Oulu; the Northern Finland Health Care Foundation; the Duodecim Foundation; the Finnish Ministry of Education and Culture (86/626/2014); the European Regional Development Fund (539/2010 A31592).
© 2017 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.