University of Oulu

Kumpulainen, S., Girchenko, P., Lahti-Pulkkinen, M., Reynolds, R., Tuovinen, S., Pesonen, A., . . . Räikkönen, K. (2018). Maternal early pregnancy obesity and depressive symptoms during and after pregnancy. Psychological Medicine, 48(14), 2353-2363. doi:10.1017/S0033291717003889

Maternal early pregnancy obesity and depressive symptoms during and after pregnancy

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Author: Kumpulainen, Satu M.1; Girchenko, Polina1; Lahti-Pulkkinen, Marius1,2,3;
Organizations: 1Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
2British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
3National Institute for Health and Welfare, Helsinki, Finland
4Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki and Oulu, Finland
5Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
6PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
7Obstetrics and Gynaecology, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland
8HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
9Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
10Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019111438011
Language: English
Published: Cambridge University Press, 2018
Publish Date: 2019-11-14
Description:

Abstract

Background: Previous studies have linked maternal obesity with depressive symptoms during and after pregnancy. It remains unknown whether obesity associates with consistently elevated depressive symptoms throughout pregnancy, predicts symptoms postpartum when accounting for antenatal symptoms, and if co-morbid hypertensive and diabetic disorders add to these associations. We addressed these questions in a sample of Finnish women whom we followed during and after pregnancy.

Methods: Early pregnancy body mass index, derived from the Finnish Medical Birth Register and hospital records in 3234 PREDO study participants, was categorized into underweight (<18.5 kg/m²), normal weight (18.5–24.99 kg/m²), overweight (25–29.99 kg/m²), and obese (⩾30 kg/m²) groups. The women completed the Center for Epidemiological Studies Depression Scale biweekly during pregnancy, and at 2.4 (S.D. = 1.2) and/or 28.2 (S.D. = 4.2) weeks after pregnancy.

Results: In comparison to normal weight women, overweight, and obese women reported higher levels of depressive symptoms and had higher odds of clinically significant depressive symptoms during (23% and 43%, respectively) and after pregnancy (22% and 36%, respectively). Underweight women had 68% higher odds of clinically significant depressive symptoms after pregnancy. Overweight and obesity also predicted higher depressive symptoms after pregnancy in women not reporting clinically relevant symptomatology during pregnancy. Hypertensive and diabetic disorders did not explain or add to these associations.

Conclusions: Maternal early pregnancy overweight and obesity and depressive symptoms during and after pregnancy are associated. Mental health promotion should be included as an integral part of lifestyle interventions in early pregnancy obesity and extended to benefit also overweight and underweight women.

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Series: Psychological medicine
ISSN: 0033-2917
ISSN-E: 1469-8978
ISSN-L: 0033-2917
Volume: 48
Issue: 14
Pages: 2353 - 2363
DOI: 10.1017/S0033291717003889
OADOI: https://oadoi.org/10.1017/S0033291717003889
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3124 Neurology and psychiatry
Subjects:
Funding: This work was supported by the Academy of Finland (K.R., grant numbers 284859, 2848591, 312670; E.K., grant numbers 127437, 129306, 130326, 134791, 263924, and 274794; H.L., grant numbers 121196, 134957, and 278941; M.L-P, grant number 285324; A-K.P.); University of Helsinki Research Funds (S.M.K., M.L-P., S.T., H.L.), British Heart Foundation (R.M.R.); Tommy's (R.M.R.); European Commission (E.K., K.R., Horizon 2020 Award SC1-2016-RTD-733280 RECAP); Foundation for Pediatric Research (E.K.); Juho Vainio Foundation (E.K.); Novo Nordisk Foundation (E.K.); Signe and Ane Gyllenberg Foundation (K.R., E.K.); Sigrid Jusélius Foundation (E.K.); Finnish Medical Foundation (H.L.); Jane and Aatos Erkko Foundation (H.L.); Päivikki and Sakari Sohlberg Foundation (H.L.); and Doctoral Program of Psychology, Learning, and Communication (S.M.K., P.G.). P.M.V, K.H, and E.H received no specific grant from any funding agency, commercial or not-for-profit sectors.
Copyright information: © Cambridge University Press 2018. This article has been published in a revised form in Psychological Medicine https://doi.org/10.1017/S0033291717003889. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.