Helena H Hauta-alus, Eero Kajantie, Elisa M Holmlund-Suila, Jenni Rosendahl, Saara M Valkama, Maria Enlund-Cerullo, Otto M Helve, Timo K Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie, High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 2, February 2019, Pages 397–407, https://doi.org/10.1210/jc.2018-00602
High pregnancy, cord blood, and infant vitamin D concentrations may predict slower infant growth
|Author:||Hauta-alus, Helena H.1; Kajantie, Eero1,2,3,4; Holmlund-Suila, Elisa M.1;|
1Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2National Institute for Health and Welfare, Helsinki, Finland
3PEDEGO Research Unit, Me Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
5Folkhälsan Research Center, Helsinki, Finland
6Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
7Department of Molecular Medicine and Surgery, Karolinska Institutet, and Clinical Genetics, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden
8Folkhälsan Institute of Genetics, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019111438212
|Publish Date:|| 2019-11-14
Context: The relationship of maternal and infant 25-hydroxyvitamin D concentration [25(OH)D] with infant growth is unclear.
Objective: Our objective was to explore whether 25(OH)D in pregnancy, umbilical cord blood (UCB), or in infancy was associated with infant growth.
Design: This study involved 798 healthy infants and their mothers in Finland. We assessed 25(OH)D during pregnancy, from UCB at birth, and from the infant at the age of 12 months.
Main Outcome Measures: Infant length, weight, length-adjusted weight, and head circumference at 6 and 12 months and midupper-arm circumference at 12 months.
Results: Of the mothers and infants, 96% and 99% were vitamin D sufficient [25(OH)D ≥50 nmol/L], respectively. Mothers with pregnancy 25(OH)D >125 nmol/L had the shortest, lightest (in weight), and thinnest (in length-adjusted weight) infants at 6 months (P for all < 0.05). For each 10 nmol/L higher UCB 25(OH)D, the infants were 0.03 SD score (SDS) shorter at 6 months (95% CI −0.05 to −0.01), adjusted for birth size, infant 25(OH)D, and parental height. Higher UCB 25(OH)D associated with smaller head circumference at 6 and 12 months (P for all <0.05) but attenuated after adjustments. Mothers with pregnancy 25(OH)D >125 nmol/L had the thinnest infants at 12 months (P = 0.021). For each 10 nmol/L higher infant 25(OH)D, the infants were 0.03 SDS lighter (−0.05 to −0.01) and 0.03 SDS thinner (−0.05 to 0.00) at 12 months.
Conclusions: Our results suggest that high pregnancy, cord blood, and infant vitamin D concentration may have disadvantageous effects on infant growth.
Journal of clinical endocrinology & metabolism
|Pages:||397 - 407|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
This work was supported by the Academy of Finland, Governmental Subsidy for Clinical Research, Foundation for Pediatric Research, Finska Läkaresällskapet, Folkhälsan Research Foundation, Sigrid Jusélius Foundation, Swedish Childhood Cancer Foundation, Stiftelsen Dorothea Olivia, Karl Walter and Jarl Walter Perkléns Minne, Päivikki and Sakari Sohlberg Foundation, Juho Vainio Foundation, Orion Research Foundation, Instrumentarium Science Foundation, the Paulo Foundation, the Finnish Medical Foundation, Victoriastiftelsen, European Commission, the Novo Nordisk Foundation, the Signe and Ane Gyllenberg Foundation, and the Yrjö Jahnsson Foundation.
© 2019 Endocrine Society. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Helena H Hauta-alus, Eero Kajantie, Elisa M Holmlund-Suila, Jenni Rosendahl, Saara M Valkama, Maria Enlund-Cerullo, Otto M Helve, Timo K Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie, High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 2, February 2019, Pages 397–407, https://doi.org/10.1210/jc.2018-00602 is available online at: https://doi.org/10.1210/jc.2018-00602.