University of Oulu

Tuovila, M., Erkinaro, T., Koivukangas, V. et al. OBES SURG (2018) 28: 3943.

Thromboelastography values remain hypercoagulative 6 months after obesity surgery : a pilot study

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Author: Tuovila, Mari1; Erkinaro, Tiina1; Koivukangas, Vesa2;
Organizations: 1Department of Anesthesia, Division of Intensive Care, Oulu University Hospital, Medical Research Center Oulu, Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, Oulu, Finland
2Division of Operative Care, Oulu University Hospital and Medical Research Center Oulu, University of Oulu, Oulu, Finland
3Nordlab Oulu Hematology Laboratory, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Springer Nature, 2018
Publish Date: 2019-11-15


Purpose: Obesity causes a prothrombotic state and is known as a predisposing factor for thromboembolic events. In this pilot study, we assessed the impact of surgery for obesity and the subsequent weight loss on blood coagulation using traditional coagulation tests and thromboelastography (TEG).

Material and Methods: We studied blood samples from 18 patients receiving bariatric surgery. Besides traditional blood coagulation tests and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation, the TEG parameters reaction time (R), kinetics time (K), angle (α), maximum amplitude (MA), clot strength (G), and lysis percent at 60 min (LY60) were determined preoperatively and on the first postoperative day and 6 months after surgery.

Results: Altogether, 54 samples were analyzed. The median MA (71.3 mm), G (12,403.3 d/sc), and hsCRP (3.5 mg/l) were elevated preoperatively. The median hsCRP further increased on the first day postoperatively, but declined to the normal range 6 months after surgery, while MA and G remained elevated. In traditional coagulation tests, there was an increase in median fibrinogen and D-dimer postoperatively. D-dimer normalized (0.4 mg/l) during the study period, while the fibrinogen level (4.1 g/l) remained above the upper limit of normal.

Conclusions: Measured by TEG, patients receiving bariatric surgery have hemostatic abnormalities indicating hypercoagulation at the 6-month follow-up visit, suggesting an elevated risk for thromboembolic events for at least 6 months after surgery.

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Series: Obesity surgery
ISSN: 0960-8923
ISSN-E: 1708-0428
ISSN-L: 0960-8923
Volume: 28
Issue: 12
Pages: 3943 - 3949
DOI: 10.1007/s11695-018-3437-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Copyright information: © Springer Science+Business Media, LLC, part of Springer Nature 2018. This is a post-peer-review, pre-copyedit version of an article published in Obesity Surgery. The final authenticated version is available online at: