Brown, AL, Al‐Samadi, A, Sperandio, M, et al. MiR‐455‐3p, miR‐150 and miR‐375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma. J Oral Pathol Med. 2019; 48: 840– 845. https://doi.org/10.1111/jop.12894
MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma
|Author:||Brown, Amy L.1; Al‐Samadi, Ahmed2; Sperandio, Marcelo1;|
1Department of Oral Pathology, Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Campinas, São Paulo, Brazil
2Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
3Institute of Biomedicine, Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland
4Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
5Medical Research Centre, Oulu University Hospital, Oulu, Finland
6Helsinki University Hospital, Helsinki, Finland
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019111943039
John Wiley & Sons,
|Publish Date:|| 2020-06-05
Background: Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical and histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) are short, non‐coding RNA sequences of 19–25 nucleotides in length that are involved in post‐transcriptional protein expression. They have been shown to play important roles in neoplastic and non‐neoplastic processes and have been suggested as diagnostic and prognostic markers.
Methods: This study, using quantitative RT–PCR, investigated miR–150, miR–455–3p and miR–375 expression, in order to identify a possible molecular distinction between AdCC and PAC.
Results: miRNA–150 and miRNA–375 expression was significantly decreased in AdCC and PAC compared with salivary gland tissue controls, whilst miRNA–455–3p showed significantly increased expression in AdCC when compared to PAC, (P < 0.05). miR–150, miR–357 and miR–455–3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) (P > 0.05).
Conclusion: MiR–455–3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases.
Journal of oral pathology & medicine
|Pages:||840 - 845|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by Fundação de Amparo á Pesquisa do Estado de São Paulo (FAPESP) (grant# 2012/10382‐5), the Sigrid Jusélius Foundation, The Finnish Cancer Society, Oulu University Hospital MRC grant, the Emil Aaltonen Foundation and Helsinki University Central Hospital Research Funds.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Brown, AL, Al‐Samadi, A, Sperandio, M, et al. MiR‐455‐3p, miR‐150 and miR‐375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma. J Oral Pathol Med. 2019; 48: 840– 845. https://doi.org/10.1111/jop.12894, which has been published in final form at https://doi.org/10.1111/jop.12894. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.