Vladimirov, D. , Niemelä, S. , Keinänen‐Kiukaanniemi, S. , Ala‐Mursula, L. , Auvinen, J. , Timonen, M. and Miettunen, J. (2018), Cloninger's Temperament Dimensions and Longitudinal Alcohol Use in Early Midlife: A Northern Finland Birth Cohort 1966 Study. Alcohol Clin Exp Re, 42: 1924-1932. doi:10.1111/acer.13857
Cloninger’s temperament dimensions and longitudinal alcohol use in early midlife : a Northern Finland Birth Cohort 1966 study
|Author:||Vladimirov, Daniel1; Niemelä, Solja2; Keinänen‐Kiukaanniemi, Sirkka1;|
1Center for Life Course Health Research, University of Oulu, Oulu, Finland
2Research Unit of Clinical Neurosciences, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019112644309
John Wiley & Sons,
|Publish Date:|| 2019-11-26
Background: Temperament is theorized to be an important factor contributing to the development of alcohol use disorder, but longitudinal studies on how temperament is related to alcohol use among general population in midlife are scarce. Our aims were to investigate potentially reciprocal associations between temperament and changes in alcohol use from age 31 to 46 using prospective birth cohort data.
Method: Within the Northern Finland Birth Cohort 1966, alcohol use and temperament were studied at ages 31 and 46. Participants (N = 5,274) were classified into moderate users, abstainers and heavy users based on their mean alcohol use (g/d). Additionally, participants were categorized as steady users, reducers, or increasers. Multinomial regression analyses were conducted with Cloninger’s Temperament and Character Inventory (TCI) scores as factors influencing alcohol use using moderate and stable users as reference groups. Reciprocity of relations was assessed with cross‐lagged structural equation modeling.
Results: Temperament and alcohol use are rather stable in midlife. Novelty seeking (NS) predicted heavy use (OR = 1.4; CI: 1.3 to 1.6 for men, OR = 1.3; CI: 1.1 to 1.5 for women) and increasing use (OR = 1.2; CI: 1.1 to 1.4 for men, OR = 1.1; CI: 1.0 to 1.3 for women), whereas low NS predicted abstaining among women (OR = 0.7; CI: 0.6 to 0.8). High harm avoidance (HA) predicted abstaining (OR = 1.3; CI: 1.1 to 1.5) for men. Low persistence (P) among men predicted both abstaining (OR = 0.9; CI: 0.7 to 0.98) and heavy use (OR = 0.9; CI: 0.8 to 0.98). Among women, low reward dependence (RD) predicted heavy use (OR = 0.8; CI: 0.7 to 0.9). Among TCI scores, only NS predicted increasing use in the cross‐lagged models.
Conclusions: Temperament has an impact on alcohol use in midlife. Of the TCI dimensions, only NS seems to predispose to increased alcohol use and problem use throughout life. Additionally, RD among women and P among men are significant factors from a life‐course perspective. Our results did not support Cloninger’s theory on type I alcoholism, as HA showed no relation to problematic alcohol use in midlife.
Alcoholism. Clinical and experimental research
|Pages:||1924 - 1932|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3141 Health care science
3124 Neurology and psychiatry
This work was supported by the Northern Finland Birth Cohort 1966, which received financial support from the Academy of Finland [268336, 104781, 120315, 129269, 1114194, 24300796]; Biocenter Oulu, Finland, University of Oulu, Finland [75617, 24002054, 2400692]; Ministry of Social Affairs and Health [50459, 50691, 50842, 2749, 2465]; National Heart, Lung and Blood Institute [5R01HL087679‐02] through the STAMPEED program [1RL1MH083268‐01]; National Institutes of Health/Mental Health [5R01MH63706:02]; ENGAGE project and grant agreement HEALTH‐F4‐2007 ; EU FP7 EurHEALTHAgeing ; Jalmari ja Rauha Ahokkaan Säätiö; European Regional Development Fund 537/2010 ; and the Medical Research Council, UK [G0500539, G0600705, G1002319, PrevMetSyn/SALVE]. The content of this manuscript has not been previously disseminated.
|Academy of Finland Grant Number:||
268336 (Academy of Finland Funding decision)
129269 (Academy of Finland Funding decision)
© 2018 by the Research Society on Alcoholism. This is the peer reviewed version of the following article: Vladimirov, D. , Niemelä, S. , Keinänen‐Kiukaanniemi, S. , Ala‐Mursula, L. , Auvinen, J. , Timonen, M. and Miettunen, J. (2018), Cloninger's Temperament Dimensions and Longitudinal Alcohol Use in Early Midlife: A Northern Finland Birth Cohort 1966 Study. Alcohol Clin Exp Re, 42: 1924-1932, which has been published in final form at https://doi.org/10.1111/acer.13857.
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