University of Oulu

Männistö J, Mentula M, Bloigu A, Gissler M, Heikinheimo O, Niinimäki M (2019) Induced abortion and future use of IVF treatment; A nationwide register study. PLoS ONE 14(11): e0225162.

Induced abortion and future use of IVF treatment : a nationwide register study

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Author: Männistö, Jaana1; Mentula, Maarit2; Bloigu, Aini1;
Organizations: 1Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland
2Department of Obstetrics and Gynecology, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland
3Finnish Institute for Health and Welfare, Helsinki, Finland
4Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Public Library of Science, 2019
Publish Date: 2019-12-02


Objective: In this nationwide study we assessed the use and factors associated with future in vitro fertilization (IVF) treatment after induced abortion.

Materials and methods: The study population was collected by means of record linkage between Finnish national registers. All women who underwent induced abortion between 2000 and 2009 in Finland were identified through the Register of Induced Abortions (n = 88 522). The study group consisted of women who underwent induced abortion and subsequently had an IVF treatment (n = 379); the comparison group were all women who had a spontaneous pregnancy and delivery 12–24 months after the index abortion (n = 7434).

Demographic characteristics at the time of index abortion, and factors associated with the abortion (gestational age at abortion, indication and method of abortion, complications after abortion) were compared between the study groups. Logistic regression was used to assess whether some of the demographic characteristics or abortion associated factors increased the use of IVF treatment in the future.

Results: The proportion of women with IVF treatment after induced abortion in the whole cohort was 0.4%. Women needing IVF treatment were older, of a higher socioeconomic status, and had fewer previous induced abortions and deliveries compared to women in the comparison group. No statistically significant differences were observed in the gestational age (≤ 12 weeks or >12 weeks of gestation) at abortion, method or complications of abortion. In multivariable analysis higher age increased, and history of previous deliveries or one or two abortions decreased the use of IVF.

Conclusions: Infertility necessitating the use of IVF treatment after induced abortion is uncommon. The factors associated with use of IVF after abortion are those generally recognized as risk factors of infertility. Abortion-related outcomes are not associated with an increased need of future IVF-treatment.

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Series: PLoS one
ISSN: 1932-6203
ISSN-E: 1932-6203
ISSN-L: 1932-6203
Volume: 14
Issue: 11
Article number: e0225162
DOI: 10.1371/journal.pone.0225162
Host publication editor: Gemmill, Alison
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: The authors received financial support from Oulu University Hospital, Helsinki University Hospital and Oulu University Research Funds.
Copyright information: © 2019 Männistö et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.