University of Oulu

Lumme, J.; Sebert, S.; Pesonen, P.; Piltonen, T.; Järvelin, M.-R.; Herzig, K.-H.; Auvinen, J.; Ojaniemi, M.; Niinimäki, M. Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study. Nutrients 2019, 11, 2831

Vitamin D levels in women with polycystic ovary syndrome : a population-based study

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Author: Lumme, Johanna1,2,3,4; Sebert, Sylvain5,6,7,8; Pesonen, Paula6;
Organizations: 1PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, 90014 Oulu, Finland
2Medical Research Center Oulu (MRC Oulu), University of Oulu, 90014 Oulu, Finland
3Department of Obstetrics and Gynecology, Oulu University Hospital, 90220 Oulu, Finland
4Department of Pediatrics and Adolescence, Oulu University Hospital, 90220 Oulu, Finland
5Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
6Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
7Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
8Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London W2 1PG, UK
9Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK
10Institute of Biomedicine, University of Oulu, 90014 Oulu, Finland
11Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 61-701 Poznan, Poland
12Oulunkaari Health Center, 91100 Ii, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2019-12-02


Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking.

Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders.

Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels.

Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.

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Series: Nutrients
ISSN: 2072-6643
ISSN-E: 2072-6643
ISSN-L: 2072-6643
Volume: 11
Issue: 11
Article number: 2831
DOI: 10.3390/nu11112831
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: J.L. was financially supported by the Päivikki and Sakari Sohlberg Foundation and the Health and Biosciences Doctoral Programme, HBS-DP (UniOGS, University of Oulu). S.S., K.-H.H., and M.-R.J. received support from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 633595 (DynaHEALTH) and grant agreement no. 733206 (LifeCycle) and from the Academy of Finland project grant 285547 (Exposomic, Genomic and Epigenomic Approach to Prediction of Metabolic and Cardiovascular Ill-Health, EGEA). T.P. received support from the Academy of Finland (315921) and Biocenter Oulu.
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
Academy of Finland Grant Number: 285547
Detailed Information: 285547 (Academy of Finland Funding decision)
315921 (Academy of Finland Funding decision)
Copyright information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (