University of Oulu

Juurikka, K.; Butler, G.S.; Salo, T.; Nyberg, P.; Åström, P. The Role of MMP8 in Cancer: A Systematic Review. Int. J. Mol. Sci. 2019, 20, 4506.

The role of MMP8 in cancer : a systematic review

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Author: Juurikka, Krista1,2; Butler, Georgina S.3,4; Salo, Tuula1,2,5,6,7;
Organizations: 1Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland
3Department of Oral Biological & Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z2, Canada
4Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
5Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
6Helsinki University Hospital, 00014 Helsinki, Finland
7Translational Immunology Research Program (TRIMM), University of Helsinki, 00014 Helsinki, Finland
8Biobank Borealis of Northern Finland, Oulu University Hospital, 90220 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.1 MB)
Persistent link:
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2019-12-02


Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting enzymes as they degrade extracellular matrix components, thus increasing the invasion of cancer cells. It has become evident, however, that MMPs can also cleave and alter the function of various non-matrix bioactive molecules, leading to both tumor promoting and suppressive effects. We applied systematic review guidelines to study MMP8 in cancer including the use of MMP8 as a prognostic factor or as a target/anti-target in cancer treatment, and its molecular mechanisms. A total of 171 articles met the inclusion criteria. The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and gastric cancers, high levels of MMP8 worsen the prognosis. Expression and genetic alterations of MMP8 can be used as a prognostic factor by examination of the tumor and serum/plasma. We conclude, that MMP8 has differing effects on cancers depending on their tissue of origin. The use of MMP8 as a prognostic factor alone, or with other factors, seems to have potential. The molecular mechanisms of MMP8 in cancer further emphasize its role as an important regulator of bioactive molecules.

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Series: International journal of molecular sciences
ISSN: 1661-6596
ISSN-E: 1422-0067
ISSN-L: 1661-6596
Volume: 20
Issue: 18
Article number: 4506
DOI: 10.3390/ijms20184506
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
Funding: This research was funded by Sigrid Juselius Foundation (K.J., T.S., P.Å.), Oulu University Hospital (K.J., P.N., grant number K10755), Cancer Society of Finland (T.S.) and Academy of Finland (P.Å., grant number 308363).
Academy of Finland Grant Number: 308363
Detailed Information: 308363 (Academy of Finland Funding decision)
Copyright information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (