Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi, Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types, Matrix Biology Plus, Volume 1, 2019, 100004, ISSN 2590-0285, https://doi.org/10.1016/j.mbplus.2019.04.001
Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types
|Author:||Izzi, Valerio1; Lakkala, Juho1; Devarajan, Raman1;|
1Oulu Center for Cell-Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland
2Centre for Cancer Biomarkers (CCBIO), Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway
|Online Access:||PDF Full Text (PDF, 2.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019121146728
|Publish Date:|| 2019-12-11
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome. Studies on the cancer matrisome have been performed for single or few neoplasms, but a more systematic analysis is still missing. Here we present a Pan-Cancer study of matrisome gene expression in 10,487 patients across 32 tumor types, supplemented with transcription factors (TFs) and driver genes/pathways regulating each tumor’s matrisome. We report on 919 TF-target pairs, either used specifically or shared across tumor types, and their prognostic significance, 40 master regulators, 31 overarching regulatory pathways and the potential for druggability with FDA-approved cancer drugs. These results provide a comprehensive transcriptional architecture of the cancer matrisome and suggest the need for development of specific matrisome-targeting approaches for future therapies.
Matrix biology plus
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
This work was supported by funds from The Academy of Finland (grants 284605, 294617, and 308867), The Jane and Aatos Erkko Foundation, The Sigrid Jusélius Foundation, The Cancer Society of Finland, The Emil Aaltonen Foundation, and The Finnish Cultural Foundation.
|Academy of Finland Grant Number:||
284605 (Academy of Finland Funding decision)
294617 (Academy of Finland Funding decision)
308867 (Academy of Finland Funding decision)
© 2019 University Of Oulu. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/).