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Hangaard, S., Gudbergsen, H., Daugaard, C.L., Bliddal, H., Nybing, J.D., Nieminen, M.T., Casula, V., Tiderius, C.‐J. and Boesen, M. (2018), Delayed gadolinium‐enhanced MRI of menisci and cartilage (dGEMRIM/dGEMRIC) in obese patients with knee osteoarthritis: Cross‐sectional study of 85 obese patients with intra‐articular administered gadolinium contrast. J. Magn. Reson. Imaging, 48: 1700-1706. doi:10.1002/jmri.26190

Delayed gadolinium-enhanced MRI of menisci and cartilage (dGEMRIM/dGEMRIC) in obese patients with knee osteoarthritis : cross-sectional study of 85 obese patients with intra-articular administered gadolinium contrast

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Author: Hangaard, Stine1,2; Gudbergsen, Henrik1; Daugaard, Cecilie L.1,2;
Organizations: 1Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
2Department of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
4Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Department of orthopedics, Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019121648357
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2019-12-16
Description:

Abstract

Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra‐articular (i.a.) delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC).

Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium‐enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA.

Study Type: Cross‐sectional.

Population: Eighty‐five obese patients with knee OA.

Field Strength/Sequences: 1.5T. Inversion recovery sequence with four inversion times.

Assessment: T1 relaxation times were calculated for posterior weight‐bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0–2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0).

Statistical Tests: T₁ relaxation times were compared using Student’s t‐test. Comparison of cartilage and meniscus T₁ relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T₁ relaxation times among the three summed morphological scores (0–2). Statistical analyses were performed with a level of significance at 0.05.

Results: For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T₁ relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T₁ relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P > 0.4).

Data Conclusion: I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T1 relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast‐saving method for cartilage.

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Series: Journal of magnetic resonance imaging
ISSN: 1053-1807
ISSN-E: 1522-2586
ISSN-L: 1053-1807
Volume: 48
Issue: 6
Pages: 1700 - 1706
DOI: 10.1002/jmri.26190
OADOI: https://oadoi.org/10.1002/jmri.26190
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
cartilage
contrast enhanced MRI
gadolinium
meniscus
osteoarthritis
Article
Funding: Contract grant sponsor: Bispebjerg and Frederiksberg Hospital; Contract grant sponsor: Danish Rheumatism Association; Contract grant sponsor: Oak Foundation; Contract grant sponsor: Velux Foundation; Contract grant sponsor: Cambridge Weight Plan UK; Contract grant sponsor: Augustinus Foundation; Contract grant sponsor: A.P. Møller Foundation for the Advancement of Medical Science.
Copyright information: © 2018 International Society for Magnetic Resonance in Medicine. This is the peer reviewed version of the following article: Hangaard, S., Gudbergsen, H., Daugaard, C.L., Bliddal, H., Nybing, J.D., Nieminen, M.T., Casula, V., Tiderius, C.‐J. and Boesen, M. (2018), Delayed gadolinium‐enhanced MRI of menisci and cartilage (dGEMRIM/dGEMRIC) in obese patients with knee osteoarthritis: Cross‐sectional study of 85 obese patients with intra‐articular administered gadolinium contrast. J. Magn. Reson. Imaging, 48: 1700-1706, which has been published in final form at https://doi.org/10.1002/jmri.26190. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.