University of Oulu

Teemu Myllylä, Mika Kaakinen, Aleksandra Zienkiewicz, Jari Jukkola, Erkki Vihriälä, Vesa Korhonen, Outi Kuittinen M.D., Lauri Eklund, and Vesa Kiviniemi M.D. "Cardiovascular effects of mannitol infusion: a comparison study performed on mouse and human", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106854A (17 May 2018);

Cardiovascular effects of mannitol infusion : a comparison study performed on mouse and human

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Author: Myllylä, Teemu1,2; Kaakinen, Mika3; Zienkiewicz, Aleksandra2;
Organizations: 1University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland
2University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland
3University of Oulu, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu, Finland
4Oulu University Hospital, Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu, Finland
5University of Oulu, Institute of Clinical Medicine, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.6 MB)
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Language: English
Published: SPIE, 2019
Publish Date: 2019-12-17


Monitoring blood-brain barrier (BBB) opening is of great interest in terms of brain drug delivery in the treatment of brain lymphoma and maybe in the future in other diseases like dementia. A method involving BBB disruption (BBBD) by mannitol infusion has been developed in University of Portland, USA, and then exploited in Oulu University Hospital in treatment of primary CSN lymphoma. Proper opening of the BBB is crucial for the treatment, yet there are no methods available for its real-time clinical monitoring. Recently, we presented a combined method using direct-current electroencephalography (DC-EEG) and near-infrared spectroscopy (NIRS) for monitoring BBBD in human. Carotid artery mannitol infusion generated a strongly lateralized DC-EEG response and in NIRS a prolonged increase in the oxy/deoxyhemoglobin ratio.

This study explores further BBBD, by focusing on monitoring its cardiovascular effects, when measured in human and mouse. For this, we used photoplethysmography (PPG) and opto-electro-mechanical sensors to gather the signals in human and mouse. Mannitol infusion in human causes strong fluctuations in blood pressure, heart rate and PPG signals, and here we discuss how the acquired signals in mouse model compares to human data.

In addition, we present our scale-free monitoring concept that enables monitoring physiological signals similarly when performing experiments in mouse and human neuroimaging setups. By combining microscopic and macroscopic imaging in mouse setup enables us to study correlations between mechanistic cellular data and clinical functional data. Further, this allows us to validate and optimize macroscopic sensing and imaging techniques aimed to be used in human imaging.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
ISBN Print: 978-1-5106-1896-1
Article number: 106854A
DOI: 10.1117/12.2307380
Host publication: Proceedings Volume 10685. Biophotonics: Photonic Solutions for Better Health Care VI, 23-26 April 2018, Strasbourg, France
Host publication editor: Popp, Jürgen
Tuchin, Valery V.
Pavone, Francesco Saverio
Conference: Biophotonics
Type of Publication: A4 Article in conference proceedings
Field of Science: 217 Medical engineering
Copyright information: © (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Self-archived with the kind permission of the publisher.