University of Oulu

Teemu Myllylä, Erkki Vihriälä, Matteo Pedone, Vesa Korhonen, Lukasz Surazynski, Maciej Wróbel, Aleksandra Zienkiewicz, Jaakko Hakala, Hannu Sorvoja, Janne Lauri, Tapio Fabritius, Małgorzata Jędrzejewska-Szczerska, Vesa Kiviniemi M.D., and Igor Meglinski "Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630M (3 March 2017);

Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

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Author: Myllylä, Teemu1; Vihriälä, Erkki1; Pedone, Matteo1,2;
Organizations: 1University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland
2University of Oulu, Center for Machine Vision and Signal Analysis Unit, Oulu, Finland
3Oulu University Hospital, Medical Research Center (MRC), Oulu, Finland
4University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland
5Gdańsk University of Technology, Faculty of Elecronics, Telecommunications and Informatics, Department of Metrology and Optoelectronics, Gdańsk, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: SPIE, 2017
Publish Date: 2019-12-17


In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia.

Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

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Series: Progress in biomedical optics and imaging
ISSN: 1605-7422
ISSN-E: 2410-9045
ISSN-L: 1605-7422
ISBN: 978-1-5106-0568-8
ISBN Print: 978-1-5106-0567-1
Article number: 100630M
DOI: 10.1117/12.2251977
Host publication: Proceedings Volume 10063, Dynamics and Fluctuations in Biomedical Photonics XIV
Host publication editor: Tuchin, Valery V.
Larin, Kirill V.
Leahy, Martin J.
Wang, Ruikang K.
Conference: Dynamics and Fluctuations in Biomedical Photonics
Type of Publication: A4 Article in conference proceedings
Field of Science: 217 Medical engineering
Funding: This study was partially funded by European Regional Development Fund, coordinated by Centre for Health and Technology, Oulu, Finland; and by Academy of Finland & JAES-grants. M.S. W. and M. J-Sz acknowledge the support of the National Science Center, Poland, grant no. 2016/20/T/ST7/00380, as well as DS Programs of the Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology. EU COST BM1205 Action "Skin Cancer Laser Imaging".
Copyright information: © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Self-archived with the kind permission of the publisher.