University of Oulu

Aleksandra Zienkiewicz, Niko Huotari, Lauri Raitamaa, Ville Raatikainen, Hany Ferdinando, Erkki Vihriälä, Vesa Korhonen, Teemu Myllylä, and Vesa Kiviniemi M.D. "Continuous blood pressure recordings simultaneously with functional brain imaging: studies of the glymphatic system", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 1006311 (3 March 2017);

Continuous blood pressure recordings simultaneously with functional brain imaging : studies of the glymphatic system

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Author: Zienkiewicz, Aleksandra1; Huotari, Niko2; Raitamaa, Lauri2;
Organizations: 1University of Oulu, Optoelectronics and Measurement Techniques Unit, 3 Erkki Koiso- Kanttilankatu, Oulu 90570, Finland
2University of Oulu, the Faculty of Medicine, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland
3Oulu University Hospital, Medical Research Center (MRC), Department of Diagnostic Radiology, Oulu, Finland, P.O. Box 50, Oulu 90029 OYS, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: SPIE, 2017
Publish Date: 2019-12-17


The lymph system is responsible for cleaning the tissues of metabolic waste products, soluble proteins and other harmful fluids etc. Lymph flow in the body is driven by body movements and muscle contractions. Moreover, it is indirectly dependent on the cardiovascular system, where the heart beat and blood pressure maintain force of pressure in lymphatic channels. Over the last few years, studies revealed that the brain contains the so-called glymphatic system, which is the counterpart of the systemic lymphatic system in the brain. Similarly, the flow in the glymphatic system is assumed to be mostly driven by physiological pulsations such as cardiovascular pulses. Thus, continuous measurement of blood pressure and heart function simultaneously with functional brain imaging is of great interest, particularly in studies of the glymphatic system.

We present our MRI compatible optics based sensing system for continuous blood pressure measurement and show our current results on the effects of blood pressure variations on cerebral brain dynamics, with a focus on the glymphatic system. Blood pressure was measured simultaneously with near-infrared spectroscopy (NIRS) combined with an ultrafast functional brain imaging (fMRI) sequence magnetic resonance encephalography (MREG, 3D brain 10 Hz sampling rate).

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Series: Progress in biomedical optics and imaging
ISSN: 1605-7422
ISSN-E: 2410-9045
ISSN-L: 1605-7422
ISBN: 978-1-5106-0568-8
ISBN Print: 978-1-5106-0567-1
Article number: 1006311
DOI: 10.1117/12.2252032
Host publication: Dynamics and Fluctuations in Biomedical Photonics XIV
Host publication editor: Tuchin, Valery V.
Larin, Kirill V.
Leahy, Martin J.
Wang, Ruikang K.
Conference: Dynamics and Fluctuations in Biomedical Photonics
Type of Publication: A4 Article in conference proceedings
Field of Science: 217 Medical engineering
3112 Neurosciences
Funding: This study was partially supported by Academy of Finland & JAES-grants.
Copyright information: © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Self-archived with the kind permission of the publisher