University of Oulu

Oura, P., Hautala, A., Kiviniemi, A., Auvinen, J., Puukka, K., Tulppo, M., Huikuri, H., Seppänen, T., Karppinen, J. (2019) Are 15-Year Trajectories of Low Back Pain and Sciatica Associated With Cardiovascular Autonomic Function in the General Population?. Spine, 44 (22), E1325-E1335. doi:10.1097/BRS.0000000000003126

Are 15-year trajectories of low back pain and sciatica associated with cardiovascular autonomic function in the general population? : the Northern Finland Birth Cohort 1966 study

Saved in:
Author: Oura, Petteri1,2; Hautala, Arto3; Kiviniemi, Antti2,4;
Organizations: 1Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland. PO Box 5000, FI-90014 University of Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. PO Box 5000, FI-90014 University of Oulu, Finland
3Faculty of Information Technology and Electrical Engineering, Center for Machine Vision and Signal Analysis, University of Oulu, Oulu, Finland. P.O. Box 5000, FI-90014 University of Oulu, Finland
4Faculty of Medicine, Research Unit of Internal Medicine, University of Oulu, Oulu, Finland. PO Box 5000, FI90014 University of Oulu, Finland
5NordLab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland. PO Box 5000, FI-90014 University of Oulu, Finland
6Finnish Institute of Occupational Health, Oulu, Finland. Aapistie 1, FI-90220 Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019121848673
Language: English
Published: Wolters Kluwer, 2019
Publish Date: 2020-11-15
Description:

Abstract

Study Design: A population-based cohort study.

Objective: The aim of this study was to examine whether 15-year trajectories of low back pain (LBP) and sciatica are associated with cardiovascular autonomic function in a large general population sample.

Summary of Background Data: Previous studies using mainly small patient samples have suggested that LBP and sciatica are associated with abnormal cardiovascular autonomic function, namely altered heart rate variability (HRV) and baroreflex sensitivity (BRS). We examined this association in a large general population sample.

Methods: The data collections of the Northern Finland Birth Cohort 1966 consisted of pain questionnaires at 31 and 46 years (history of LBP, sciatica, and other musculoskeletal pains during the previous year; yes/no for each) and measurements of HRV and BRS at 46 years (heart rate, HR; root mean square of successive differences in beat-to-beat intervals, rMSSD; low-frequency systolic blood pressure variability, SBPV; cross-spectral BRS, BRS; each while seated and standing). The data collections also comprised several confounders. Trajectories for LBP, sciatica, and both together (“no pain,” “decreasing,” “increasing,” “long-term pain”) were constructed and general linear models were used to perform comparisons between trajectories (for HR/rMSSD, n = 3398; for SBPV/BRS, n = 1667).

Results: In the crude models, LBP and sciatica were associated with higher HR, lower rMSSD, higher SBPV, and lower BRS, but these associations were mostly attenuated by adjustments. Regarding both LBP and sciatica, only the “increasing” trajectory was associated with two of the eight outcomes (standing SBPV, seated BRS) after adjustments. Regarding LBP, the “increasing” trajectory was associated with three (standing SBPV, seated BRS, standing BRS), the “long-term pain” trajectory with one (standing BRS), and the “decreasing” trajectory with one outcome (seated SBPV) after adjustments. Sciatica showed no association with the outcomes after adjustments.

Conclusion: We conclude that the 15-year trajectories of LBP and sciatica do not have a consistent independent association with cardiovascular autonomic function among the general population.

see all

Series: Spine
ISSN: 0362-2436
ISSN-E: 1528-1159
ISSN-L: 0362-2436
Volume: 44
Issue: 22
Pages: E1325 - E1335
DOI: 10.1097/BRS.0000000000003126
OADOI: https://oadoi.org/10.1097/BRS.0000000000003126
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
3142 Public health care science, environmental and occupational health
Subjects:
Funding: The funds of Tekes – the Finnish Funding Agency for Technology and Innovation were received in support of work. NFBC1966 received financial support from the University of Oulu (Grant no. 65354, 24000692), Oulu University Hospital (Grant no. 2/97, 8/97, 24301140), the Ministry of Health and Social Affairs (Grant no. 23/251/97, 160/97, 190/97), the National Institute for Health and Welfare, Helsinki (Grant no. 54121), the Regional Institute of Occupational Health, Oulu, Finland (Grant no. 50621, 54231), and the European Regional Development Fund (Grant no. 539/2010 A31592).
Copyright information: © 2019 Wolters Kluwer Health, Inc. All rights reserved.