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Knuutinen, O., Kuitunen, H., Alahuhta, S., Isokangas, J.-M., Sonkajärvi, E., Turpeenniemi-Hujanen, T., & Kuittinen, O. (2018). Case Report: Chemotherapy in Conjunction With Blood–Brain Barrier Disruption for a Patient With Germ Cell Tumor With Multiple Brain Metastases. Clinical Genitourinary Cancer, 16(5), e993–e996. https://doi.org/10.1016/j.clgc.2018.05.005

Case report: chemotherapy in conjunction with blood–brain barrier disruption for a patient with germ cell tumor with multiple brain metastases

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Author: Knuutinen, Oula1; Kuitunen, Hanne2; Alahuhta, Seppo3;
Organizations: 1Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland
2Department of Oncology, Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland
3Department of Anaesthesiology, Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland
4Department of Diagnostic Radiology, Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019122049243
Language: English
Published: Elsevier, 2018
Publish Date: 2019-12-20
Description:

Clinical practice points

Testicular cancer with brain metastases is related to poor prognosis because the penetration of chemotherapeutic agents is decreased by the blood–brain barrier.

The standard treatment of brain metastases—whole brain radiation therapy combined with chemotherapy—is related to a limited increase in survival and considerable deleterious cognitive effects.

The blood–brain barrier can be transiently disrupted using hyperosmolar intra-arterial mannitol injection. When combined with intra-arterial chemotherapy, therapeutic intratumoral concentrations can be attained.

In experienced centers, blood–brain barrier disruption therapy is relatively safe with a low incidence of catheter-related complications.

Blood–brain barrier disruption therapy is a promising treatment modality for brain metastases as an alternative to whole brain radiation therapy.

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Series: Clinical genitourinary cancer
ISSN: 1558-7673
ISSN-E: 1938-0682
ISSN-L: 1558-7673
Volume: 16
Issue: 5
Pages: e993 - e996
DOI: 10.1016/j.clgc.2018.05.005
OADOI: https://oadoi.org/10.1016/j.clgc.2018.05.005
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
BBBD therapy
Intra-arterial chemotherapy
Neuro-oncology
Neuropharmacology
Testicular neoplasms
Article
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/
  https://creativecommons.org/licenses/by-nc-nd/4.0/