University of Oulu

Evgeny A. Zherebtsov, Elena V. Zharkikh, Igor O. Kozlov, Yulia I. Loktionova, Angelina I. Zherebtsova, Ilya E. Rafailov, Sergei G. Sokolovski, Victor V. Sidorov, Andrey V. Dunaev, and Edik U. Rafailov "Wearable sensor system for multipoint measurements of blood perfusion: pilot studies in patients with diabetes mellitus", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791O (22 July 2019);

Wearable sensor system for multipoint measurements of blood perfusion : pilot studies in patients with diabetes mellitus

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Author: Zherebtsov, Evgeny A.1,2; Zharkikh, Elena V.2; Kozlov, Igor O.2;
Organizations: 1Optoelectronics and Measurement Techniques, University of Oulu, Oulu, FI-90014, Finland
2Research and Development Center of Biomedical Photonics, Orel State University named after I.S. Turgenev, Orel, Russia
3Aston Medical Technology Ltd., Birmingham, UK
4Aston Institute of Photonic Technologies, Aston University, Birmingham, UK
5SPE "LAZMA" Ltd, Moscow, Russia
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: SPIE, 2019
Publish Date: 2020-01-10


The growing interest in the development of new wearable electronic devices for mobile healthcare provides great opportunities for the development of methods for assessing blood perfusion in this direction. Laser Doppler flowmetry (LDF) is one of the promising methods. A fine analysis of capillary blood ow structure and rhythm in the time and frequency domains, coupled with a new possibility of round-the-clock monitoring can provide valuable diagnostic information about the state of microvascular blood ow. In this study, wearable implementation of laser Doppler flowmetry was utilised for microcirculatory function assessment in patients with diabetes and healthy controls of two distinct age groups. Four wearable laser Doppler flowmetry monitors were used for the analysis of blood microcirculation. Thirty-seven healthy volunteers and 18 patients with type 2 diabetes mellitus participated in the study. The results of the studies have shown that the average perfusion differs between healthy volunteers of distinct age groups and between healthy volunteers of the younger age group and patients with diabetes mellitus. It was noted that the average level of perfusion measured on the wrist in the two groups of healthy volunteers has no statistically significant differences found in similar measurements on the fingertips. The wearable implementation of LDF can become a truly new diagnostic interface to monitor cardiovascular parameters, which could be of interest for diagnostics of conditions associated with microvascular disorders.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
ISBN Print: 978-1-5106-2851-9
Article number: 110791O
DOI: 10.1117/12.2526966
Host publication: Medical Laser Applications and Laser-Tissue Interactions IX 2019
Host publication editor: Lilge, Lothar D.
Philipp, Carsten M.
Conference: Progress in Biomedical Optics and Imaging
Type of Publication: A4 Article in conference proceedings
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
Funding: This study was funded by the Russian Science Foundation (the research project 18-79-00237). Evgeny Zherebtsov kindly acknowledges for personal support from grant of Academy of Finland No.318281 (data processing).
Academy of Finland Grant Number: 318281
Detailed Information: 318281 (Academy of Finland Funding decision)
Copyright information: © (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only. Self-archived with the kind permission by the publisher.