University of Oulu

Remes, S. and Kulmala, P. (2018), The interplay between risk and preventive factors explains why some children develop allergies to certain foods and others show tolerance. Acta Paediatr, 107: 1677-1683. doi:10.1111/apa.14391

The interplay between risk and preventive factors explains why some children develop allergies to certain foods and others show tolerance

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Author: Remes, Sami1; Kulmala, Petri2
Organizations: 1Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland
2PEDEGO Research Unit and Medical Research Center (MRC) Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202001131831
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2020-01-13
Description:

Abstract

Aim: A number of studies have clarified the tolerance mechanisms and risk factors for food allergies. Our aim was to explore food allergy symptoms by target organs, together with the risk factors and how to prevent food allergies and induce tolerance.

Methods: We carried out a thorough review of studies on paediatric food allergies published in the last decade.

Results: Food allergy symptoms may affect the skin, nasal and oral mucosa, conjunctivae, gastrointestinal tract or, in severe cases, the respiratory tract and cardiovascular organs. Immunoglobulin E (IgE)‐mediated symptoms appear rapidly after exposure to the offending allergen, whereas non‐IgE‐mediated symptoms are typically delayed. The immunological processes involved in non‐IgE‐mediated allergic reactions are poorly understood, but T‐cell activation is probably involved. There are several factors that influence the food sensitisation process: genetic predisposition, disruption of oral tolerance development, impaired skin barriers in atopic eczema and the influence of microbiomes.

Conclusion: The symptoms and intensity of reactions vary considerably with regard to food allergies, and these depend on the individual's concomitant immunological and regulatory mechanisms. There is strong evidence that dietary diversity is important for children, even when they come from families with high allergy risks.

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Series: Acta pædiatrica
ISSN: 0803-5253
ISSN-E: 1651-2227
ISSN-L: 0803-5253
Volume: 107
Issue: 10
Pages: 1677 - 1683
DOI: 10.1111/apa.14391
OADOI: https://oadoi.org/10.1111/apa.14391
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2018 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Remes, S. and Kulmala, P. (2018), The interplay between risk and preventive factors explains why some children develop allergies to certain foods and others show tolerance. Acta Paediatr, 107: 1677-1683, which has been published in final form at https://doi.org/10.1111/apa.14391. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.