University of Oulu

Ville Tikkanen, Virva Siira, Karl-Erik Wahlberg, Helinä Hakko, Kristian Läksy, Riikka Roisko, Mika Niemelä, Sami Räsänen, Adolescent social functioning in offspring at high risk for schizophrenia spectrum disorders in the Finnish Adoptive Family Study of Schizophrenia, Schizophrenia Research, Volume 215, 2020, Pages 293-299, ISSN 0920-9964, https://doi.org/10.1016/j.schres.2019.10.013

Adolescent social functioning in offspring at high risk for schizophrenia spectrum disorders in the Finnish Adoptive Family Study of Schizophrenia

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Author: Tikkanen, Ville1,2; Siira, Virva1; Wahlberg, Karl-Erik2;
Organizations: 1Faculty of Education, P.O. Box 2000, 90014, University of Oulu, Finland
2University of Oulu, Department of Psychiatry, Unit of Clinical Neuroscience, P.O. Box 5000, 90014, University of Oulu, Finland
3Oulu University Hospital, Department of Psychiatry, P.O. Box 26, 90029, Oulu University Hospital, Finland
4Social Security Institute of Finland (SSI), Finland
5University of Oulu, Department of Medicine, Center for Life Course Health, Research, P.O. Box 5000, 90014, University of Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe202001142070
Language: English
Published: Elsevier, 2020
Publish Date: 2020-11-04
Description:

Abstract

Background: Children and adolescents with a genetic risk for schizophrenia are often found to have poorer social functioning compared to their controls. However, less is known about high-risk offspring who have not been reared by a biological parent with schizophrenia. The purpose of this study was to examine deficits in social functioning in adolescence as a possible factor related to genetic vulnerability to schizophrenia spectrum disorders, and also to examine possible gender differences in these associations.

Method: The present sample consisted of 88 genetic high-risk (HR) adoptees whose biological mothers were diagnosed with schizophrenia spectrum disorders and 83 genetic low-risk (LR) adoptees with biological mothers with non-schizophrenia spectrum disorders or no psychiatric disorders. Adoptees’ social functioning at ages 16–20 was assessed using the UCLA Social Attainment Survey.

Results: Compared to LR adoptees, HR adoptees displayed statistically significant deficits in their peer relationships, involvement in activities and overall social functioning during adolescence. HR males were distinguished from LR males by their significantly poorer overall social functioning. Compared to HR females, HR males showed significant deficits in their romantic relationships. Of marginal significance was that HR females displayed more social functioning deficits relative to LR females, mainly in the areas of peer relationships, involvement in activities and overall social functioning.

Conclusions: These results from the adoption and high-risk study design suggest that deficits in social functioning in adolescence may be related to genetic vulnerability to schizophrenia spectrum disorders and that some of these deficits may be gender-specific.

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Series: Schizophrenia research
ISSN: 0920-9964
ISSN-E: 1573-2509
ISSN-L: 0920-9964
Volume: 215
Pages: 293 - 299
DOI: 10.1016/j.schres.2019.10.013
OADOI: https://oadoi.org/10.1016/j.schres.2019.10.013
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
515 Psychology
Subjects:
Funding: The Finnish Adoptive Family Study of Schizophrenia has been supported by Grant MH 39663 from the Public Health Service, grants from the Scottish Rite Schizophrenia Research and from the Rite Schizophrenia Research Program, N.M.J., U.S.A, and the Academy of Finland. This study was supported by Oulu University Hospital.
Copyright information: © 2019 The Authors. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
  https://creativecommons.org/licenses/by-nc-nd/4.0/