University of Oulu

Munger, K.L., Hongell, K., Cortese, M., Åivo, J., Soilu‐Hänninen, M., Surcel, H.‐M. and Ascherio, A. (2019), Epstein–barr virus and multiple sclerosis risk in the finnish maternity cohort. Ann Neurol, 86: 436-442. doi:10.1002/ana.25532

Epstein–Barr virus and multiple sclerosis risk in the Finnish Maternity Cohort

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Author: Munger, Kassandra L.1; Hongell, Kira2; Cortese, Marianna1;
Organizations: 1Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA
2Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland
3University of Oulu, Faculty of Medicine, Oulu, Finland
4Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland
5Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe202001212910
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-08-14
Description:

Abstract

Objective: To determine whether maternal Epstein–Barr virus (EBV) IgG antibody levels are associated with risk of multiple sclerosis (MS) in the offspring.

Methods: We conducted a prospective nested case–control study in the Finnish Maternity Cohort (FMC) with serum samples from >800,000 women collected during pregnancy since 1983. Cases of MS among offspring born between 1983 and 1991 were identified via hospital and prescription registries; 176 cases were matched to up to 3 controls (n = 326) on region and dates of birth, sample collection, and mother‘s birth. We used conditional logistic regression to estimate relative risks (RRs) and adjusted models for sex of the child, gestational age at sample collection, and maternal serum 25‐hydroxyvitamin D and cotinine levels. Similar analyses were conducted among 1,049 women with MS and 1,867 matched controls in the FMC.

Results: Maternal viral capsid antigen IgG levels during pregnancy were associated with an increased MS risk among offspring (RRtop vs bottom quintile = 2.44, 95% confidence interval [CI] = 1.20–5.00, p trend = 0.004); no associations were found between maternal EBV nuclear antigen 1 (EBNA‐1), diffuse early antigen, or cytomegalovirus IgG levels and offspring MS risk. Among women in the FMC, those in the highest versus lowest quintile of EBNA‐1 IgG levels had a 3‐fold higher risk of MS (RR = 3.21, 95% CI = 2.37–4.35, p trend <1.11e‐16). These associations were not confounded or modified by 25‐hydroxyvitamin D.

Interpretation: Offspring of mothers with high viral capsid antigen IgG during pregnancy appear to have an increased risk of MS. The increase in MS risk among women with elevated prediagnostic EBNA‐1 IgG levels is consistent with previous results.

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Series: Annals of neurology
ISSN: 0364-5134
ISSN-E: 1531-8249
ISSN-L: 0364-5134
Volume: 86
Issue: 3
Pages: 436 - 442
DOI: 10.1002/ana.25532
OADOI: https://oadoi.org/10.1002/ana.25532
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, A.A.). The funding agency had no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, or the decision to submit the manuscript for publication.
Copyright information: © 2019 American Neurological Association. This is the peer reviewed version of the following article: Munger, K.L., Hongell, K., Cortese, M., Åivo, J., Soilu‐Hänninen, M., Surcel, H.‐M. and Ascherio, A. (2019), Epstein–barr virus and multiple sclerosis risk in the finnish maternity cohort. Ann Neurol, 86: 436-442, which has been published in final form at https://doi.org/10.1002/ana.25532. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.