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The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood |
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| Author: | Westberg, Anna P.1,2; Kautiainen, Hannu1,3; Salonen, Minna K.1,4; |
| Organizations: |
1Folkhälsan Research Center, Helsinki, Finland 2Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 3Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland
4Department of Public Health Solutions, Unit of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
5Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 6PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 7Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland 8National University of Singapore, Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology, Singapore 9Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe202002104955 |
| Language: | English |
| Published: |
Elsevier,
2019
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| Publish Date: | 2020-11-13 |
| Description: |
AbstractAims: We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods: This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied. Results: There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p < 0.001) and mean homeostatic model assessment of insulin resistance (HOMA-IR) (p = 0.049). According to the subjects’ own BMI, high maternal BMI was associated with lower 2-hour glucose concentrations only in non-obese men and with lower HOMA-IR only in obese men. Maternal BMI was not associated with glucose concentrations nor with HOMA-IR in women. In addition, maternal BMI was positively associated with a higher offspring lean body mass in men. Conclusions: High maternal BMI was associated with lower 2-hour plasma glucose concentration, especially in non-obese men. Offspring lean body mass may be a mediating factor for the association. see all
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| Series: |
Diabetes research and clinical practice |
| ISSN: | 0168-8227 |
| ISSN-E: | 1872-8227 |
| ISSN-L: | 0168-8227 |
| Volume: | 158 |
| Article number: | 107926 |
| DOI: | 10.1016/j.diabres.2019.107926 |
| OADOI: | https://oadoi.org/10.1016/j.diabres.2019.107926 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
HBCS was supported by Emil Aaltonen Foundation, Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Finnish Foundation for Pediatric Research, Juho Vainio Foundation, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) grant agreement no 278603 and EU H2020-PHC-2014-DynaHealth grant no. 633595. The Academy of Finland supported MBvB (grant no. 257239), EK (grant no. 127437, 129306, 130326, 134791 and 2639249) JGE (grant no. 129369, 129907, 135072, 129255 and 126775). |
| EU Grant Number: |
(633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging |
| Copyright information: |
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |