University of Oulu

Tuomisto AE, Mäkinen MJ, Väyrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25(31): 4383-4404.

Systemic inflammation in colorectal cancer : underlying factors, effects, and prognostic significance

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Author: Tuomisto, Anne E.1,2; Markus J Mäkinen, Markus J.1,2; Väyrynen, Juha P.1,2,3
Organizations: 1Cancer and Translational Medicine Research Unit, University of Oulu, Oulu 90220, Finland
2Department of Pathology, Oulu University Hospital and Medical Research Center Oulu, Oulu 90220, Finland
3Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, United States
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3 MB)
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Language: English
Published: Baishideng Publishing Group, 2019
Publish Date: 2020-02-18


Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40% of colorectal cancer patients. The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation. While the low-level systemic inflammation is often clinically silent, its consequences are many and may ultimately lead to chronic cancer-associated wasting, cachexia. In this review, we discuss the pathogenesis of cancer-related systemic inflammation, explore the role of systemic inflammation in promoting cancer growth, escaping antitumor defense, and shifting metabolic pathways, and how these changes are related to less favorable outcome.

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Series: World journal of gastroenterology
ISSN: 1007-9327
ISSN-E: 2219-2840
ISSN-L: 1007-9327
Volume: 25
Issue: 31
Pages: 4383 - 4404
DOI: 10.3748/wjg.v25.i31.4383
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
3121 General medicine, internal medicine and other clinical medicine
Copyright information: © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.