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Sirniö, P., Väyrynen, J.P., Klintrup, K. et al. Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival. Br J Cancer 120, 238–246 (2019). https://doi.org/10.1038/s41416-018-0357-6

Alterations in serum amino-acid profile in the progression of colorectal cancer : associations with systemic inflammation, tumour stage and patient survival

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Author: Sirniö, Päivi1,2; Väyrynen, Juha P.1,2; Klintrup, Kai2,3;
Organizations: 1Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014, Oulu, Finland
2Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029, Oulu, Finland
3Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014, Oulu, Finland
4Department of Physiology, Research Unit of Biomedicine and Biocenter Oulu, University of Oulu, POB 5000, 90014, Oulu, Finland
5Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572, Poznan, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202002216172
Language: English
Published: Springer Nature, 2019
Publish Date: 2020-02-21
Description:

Abstract

Background: Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein degradation and release of amino acids (AAs) in skeletal muscle are stimulated in cachexia. Here, we define factors contributing to serum AA levels in colorectal cancer (CRC).

Methods: Serum levels of nine AAs were characterised in 336 CRC patients and their relationships with 20 markers of systemic inflammatory reaction, clinicopathological features of cancers and patient survival were analysed.

Results: Low serum glutamine and histidine levels and high phenylalanine levels associated with indicators of systemic inflammation, including high modified Glasgow Prognostic Score, high blood neutrophil/lymphocyte ratio and high serum levels of CRP, IL-6 and IL-8. Low levels of serum glutamine, histidine, alanine and high glycine levels also associated with advanced cancer stage and with poor cancer-specific survival in univariate analysis.

Conclusions: In CRC, serum AA levels are associated with systemic inflammation and disease stage. These findings may reflect muscle catabolism induced by systemic inflammation in CRC.

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Series: British journal of cancer
ISSN: 0007-0920
ISSN-E: 1532-1827
ISSN-L: 0007-0920
Volume: 120
Pages: 238 - 246
DOI: 10.1038/s41416-018-0357-6
OADOI: https://oadoi.org/10.1038/s41416-018-0357-6
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Article
Funding: This work was supported by grants from Thelma Mäkikyrö Foundation, Emil Aaltonen Foundation, Finnish Cancer Society, K. Albin Johansson Foundation and Orion Research Foundation.
Copyright information: © Cancer Research UK 2018. This work is published under the standard license to publish agreement. After12 months the work will become freely available and the license terms will switch toa Creative Commons Attribution 4.0 International (CC BY 4.0).
  https://creativecommons.org/licenses/by/4.0/