University of Oulu

Heikkinen, I., Bello, I., Wahab, A., Hagström, J., Haglund, C., Coletta, R., Nieminen, P., Mäkitie, A., Salo, T., Leivo, I., Almangush, A. (2019) Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer, 43 (10), 1392-1396. doi:10.1097/PAS.0000000000001323

Assessment of tumor-infiltrating lymphocytes predicts the behavior of early-stage oral tongue cancer

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Author: Heikkinen, Ilkka1,2; Bello, Ibrahim O.3,1; Wahab, Awais1,2;
Organizations: 1Department of Pathology, University of Helsinki, Helsinki, Finland
2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
3Department of Oral Medicine and Diagnostic Sciences, King Saud University College of Dentistry, Riyadh, Saudi Arabia
4Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland
5Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil
7Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland
8Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
9Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
10Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
11Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
12Institute of Biomedicine, Pathology, University of Turku, Turku, Finland
13Institute of Dentistry, University of Misurata, Misurata, Libya
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: Wolters Kluwer, 2019
Publish Date: 2020-02-24


Tumor-infiltrating lymphocytes (TILs) have shown a promising prognostic value in many epithelial cancers. We sought to assess the prognostic value of TILs in a multicenter cohort of early oral tongue squamous cell carcinoma (OTSCC). The percentage of TILs was assessed on the surgical resection slides stained with hematoxylin and eosin. The assessment of TILs was performed in the stromal compartment and in the intraepithelial compartment (at the invasive front and at the center of the tumor). We followed the method that was described recently by the International Immuno-Oncology Biomarker Working Group for the assessment of TILs. A total of 308 cases from the 5 Finnish university hospitals and from A.C. Camargo Cancer Center, São Paulo, Brazil, were included. We found a promising prognostic value for stromal TILs at the invasive front in the multivariable analysis with a hazard ratio of 2.61 (95% confidence interval [CI], 1.77‐3.83; P<0.001) for overall survival, 1.99 (95% CI, 1.07‐3.69; P=0.040) for disease-specific survival, and 1.94 (95% CI, 1.14‐3.29; P=0.020) for disease-free survival. In conclusion, evaluation of TILs is simple and can aid in identifying the high-risk cases of early OTSCC. The method introduced by the International Immuno-Oncology Biomarker Working Group can be used for standardized determination of TILs in early OTSCC.

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Series: The American journal of surgical pathology
ISSN: 0147-5185
ISSN-E: 1532-0979
ISSN-L: 0147-5185
Volume: 43
Issue: 10
Pages: 1392 - 1396
DOI: 10.1097/PAS.0000000000001323
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Copyright information: © 2019 Wolters Kluwer Health, Inc. All rights reserved.