University of Oulu

Katisko K, Cajanus A, Korhonen T, Remes AM, Haapasalo A and Solje E (2019) Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers. Front. Neurosci. 13:658. doi: 10.3389/fnins.2019.00658

Prodromal and early bvFTD : evaluating clinical features and current biomarkers

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Author: Katisko, Kasper1; Cajanus, Antti1; Korhonen, Titta1;
Organizations: 1Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, Finland
2Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland
3Research Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland
4Medical Research Center, Oulu University Hospital, Oulu, Finland
5A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Frontiers Media, 2019
Publish Date: 2020-02-25


Despite the current diagnostic criteria, early diagnostics of behavioral variant of frontotemporal dementia (bvFTD) has remained challenging. Patients with bvFTD often present with misleading psychiatric phenotype, and, on the other hand, impairment in memory functions have increasingly been reported. However, impaired episodic memory is currently considered as an exclusion criterion for bvFTD. Single biofluid-based or imaging biomarkers do not currently provide sufficient sensitivity or specificity for early bvFTD diagnosis at single-subject level, although studies have suggested improved accuracy with different biomarker combinations. In this mini review, we evaluate the core clinical features of early bvFTD and summarize the most potential imaging and fluid biomarkers for bvFTD diagnostics.

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Series: Frontiers in neuroscience
ISSN: 1662-4548
ISSN-E: 1662-453X
ISSN-L: 1662-4548
Volume: 13
Article number: 658
DOI: 10.3389/fnins.2019.00658
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3124 Neurology and psychiatry
3112 Neurosciences
Funding: This work was supported by the Academy of Finland, grant numbers 315459 and 315460, Finnish Medical Foundation, Finnish Brain Foundation, Päivikki and Sakari Sohlberg Foundation, Finnish Alzheimer’s Disease Research Society, Maire Taponen Foundation, Finnish Cultural Foundation, Olvi Foundation, and Yrjö Jahnsson Foundation, grant number 20187070.
Academy of Finland Grant Number: 315459
Detailed Information: 315459 (Academy of Finland Funding decision)
315460 (Academy of Finland Funding decision)
Copyright information: © 2019 Katisko, Cajanus, Korhonen, Remes, Haapasalo and Solje. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.