University of Oulu

O. Stelmashchuk, Y. Tarakanchikova, E. Seryogina, G. Piavchenko, E. Zherebtsov, A. Dunaev, A. Popov, and I. Meglinski "Noninvasive control of rhodamine-loaded capsules distribution in vivo", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 1071619 (26 April 2018);

Noninvasive control of rhodamine-loaded capsules distribution in vivo

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Author: Stelmashchuk, O.1; Tarakanchikova, Y.2,3,4; Seryogina, E.1;
Organizations: 1Research and Development Center of Biomedical Photonics, Orеl State University named after I.S. Turgenev, Komsomolskaya 95, Orel, 302026, Russia
2Opto-Electronics and Measurement Techniques Research Unit, University of Oulu, Erkki Koiso-Kanttilankatu 3, Oulu, 90570, Finland
3Saratov State University, Astrakhanskaya 83, Saratov, 410012, Russia
4First I.P. Pavlov State Medical University of St. Petersburg, Lev Tolstoy str. 6/8, Saint-Petersburg, 197022, Russia
5Centre of Preclinical Research, CJSC “Retinoids”, Plekhanova 2/46-5, Moscow, 111123, Russia
6Aston Institute of Photonic Technologies, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
7Terahertz Biomedicine Laboratory, ITMO University, St. Petersburg, 197101, Russia
8Institute of Biology, Irkutsk State University, 3 Lenina Str., Irkutsk, 664003, Russia
9National Research Nuclear University “MEPhI”, Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, 115409, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: SPIE, 2018
Publish Date: 2020-03-03


Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

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Series: Progress in biomedical optics and imaging
ISSN: 1605-7422
ISSN-E: 2410-9045
ISSN-L: 1605-7422
ISBN Print: 978-1-5106-2001-8
Article number: 1071619
DOI: 10.1117/12.2315773
Host publication: Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Host publication editor: Genina, E. A.
Goryacheva, I. Y.
Tuchin, V. V.
Conference: Optical Technologies in Biophysics and Medicine
Type of Publication: A4 Article in conference proceedings
Field of Science: 1182 Biochemistry, cell and molecular biology
213 Electronic, automation and communications engineering, electronics
Funding: This work was supported by the Russian Foundation on Innovations U.M.N.I.K., 2017 SPIE Optics and Photonics Education Scholarship, CIMO Fellowship (TM-15-9729, YT), EDUFI Fellowship (TM-17-10389, YT), Russian Government (grant No. 074-U01, AP, IM), Russian Science Foundation (grant No. 15-14-10008, IM), MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005, IM), Academy of Finland (grant No. 290596, AP). EZ kindly acknowledges the funding from the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 703145.
Academy of Finland Grant Number: 290596
Detailed Information: 290596 (Academy of Finland Funding decision)
Copyright information: © (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.