University of Oulu

Viktor V. Dremin, Evgeny A. Zherebtsov, Victor V. Sidorov, Alexander I. Krupatkin M.D., Irina N. Makovik, Angelina I. Zherebtsova, Elena V. Zharkikh, Elena V. Potapova, Andrey V. Dunaev, Alexander A. Doronin, Alexander V. Bykov, Ilya E. Rafailov, Karina S. Litvinova, Sergei G. Sokolovski, and Edik U. Rafailov "Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus," Journal of Biomedical Optics 22(8), 085003 (19 August 2017).

Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus

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Author: Dremin, Viktor V.1; Zherebtsov, Evgeny A.2; Sidorov, Victor V.3;
Organizations: 1Orel State University named after I.S. Turgenev, Biomedical Photonics Laboratory of University Clinic, Orel, Russia
2Aston University, Aston Institute of Photonic Technologies, Optoelectronics and Biomedical Photonics Group, Birmingham, United Kingdom
3SPE “LAZMA” Ltd., Moscow, Russia
4Priorov Central Research Institute of Traumatology and Orthopaedics, Moscow, Russia
5Yale University, Department of Computer Science, Computer Graphics Group, New Haven, Connecticut, United States
6University of Oulu, Optoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, Oulu, Finland
7Aston University, School of Engineering and Applied Sciences, Aston Institute of Photonic Technologies, Birmingham, United Kingdom
8Aston University, Aston Medical School, Birmingham, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.1 MB)
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Language: English
Published: SPIE, 2017
Publish Date: 2020-03-04


According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

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Series: Journal of biomedical optics
ISSN: 1083-3668
ISSN-E: 1560-2281
ISSN-L: 1083-3668
Volume: 22
Issue: 8
Article number: 085003
DOI: 10.1117/1.JBO.22.8.085003
Type of Publication: A1 Journal article – refereed
Field of Science: 215 Chemical engineering
Funding: This work was supported by funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 703145. The authors also acknowledge the support of the Academy of Finland (grants: 296408 and 290596) as well as a grant of the President of the Russian Federation for state support of young Russian scientists No. MK-7168.2016.8. Special thanks are extended to doctors Alimicheva E.A., Masalygina G.I., and Muradyan V.F. of the Orel Regional Clinical Hospital for providing useful advice and help.
Academy of Finland Grant Number: 296408
Detailed Information: 296408 (Academy of Finland Funding decision)
290596 (Academy of Finland Funding decision)
Copyright information: © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JBO.22.8.085003].