University of Oulu

Vainionpää, A, Tuomi, J, Kantola, S, Anttonen, V. Neonatal thrush of newborns: Oral candidiasis? Clin Exp Dent Res. 2019; 5: 580– 582.

Neonatal thrush of newborns : oral candidiasis?

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Author: Vainionpää, Anne1,2; Tuomi, Jenni1; Kantola, Saara3;
Organizations: 1Research Unit of Oral Health Sciences, University of Oulu, Oulu, Finland
2Department of Special Dentistry Unit, Oral Health Care of City of Oulu, Oulu, Finland
3Department of Oral and Maxillofacial Diseases, Oulu University Hospital, Oulu, Finland
4Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-03-04


Objectives: Neonatal thrush, also called oral candidiasis, is commonly a clinical diagnosis based on white patches on oral mucosal surfaces. Candida albicans is often associated with it. This clinical study aimed to investigate the presence of C. albicans among newborns with or without clinical findings of candidiasis on oral mucosa. Another aim was to investigate how thrush responded to current therapy by acidic liquids such as lingonberry or lemon juice.

Material and methods: Swipe samples were collected from 32 healthy, full‐term infants younger than 12 months with or without white patches on oral mucosa. Clinical diagnosis of thrush was made by a community nurse based on thick and yellowish white patches. The routine therapy was oral lingonberry or lemon juice or soda water. Disappearing of patches was controlled by a phone call about 2 weeks after the baseline. Both parents and nurses gave background factors by filling a questionnaire.

Results: One (3%) infant without clinical signs was diagnosed with Candida parapsilosis, none with C. albicans. Thrush resembling candidiasis was diagnosed clinically in four (12.5%) children. Three out of four parents reported persisting findings after 2 weeks. Only the maternal mastitis and use of antibiotics were significantly associated with thrush (p = .001). C. albicans was not discovered from babies with clinical thrush.

Conclusions: Aetiology of the white patches remained unclear. The current way of treating them with acidic liquids is not efficient. Additional studies are needed.

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Series: Clinical and experimental dental research
ISSN: 2057-4347
ISSN-E: 2057-4347
ISSN-L: 2057-4347
Volume: 5
Issue: 5
Pages: 580 - 582
DOI: 10.1002/cre2.213
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Funding: A.V. would like to thank The Finnish Dental Society Apollonia for financial support for this research.
Copyright information: © 2019 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.