Minkeviciene R, Hlushchenko I, Virenque A, Lahti L, Khanal P, Rauramaa T, Koistinen A, Leinonen V, Noe FM and Hotulainen P (2019) MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Front. Mol. Neurosci. 12:276. doi: 10.3389/fnmol.2019.00276
MIM-deficient mice exhibit anatomical changes in dendritic spines, cortex volume and brain ventricles, and functional changes in motor coordination and learning
|Author:||Minkeviciene, Rimante1; Hlushchenko, Iryna1; Virenque, Anaïs2,3;|
1Minerva Foundation Institute for Medical Research, Helsinki, Finland
2A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
3HiLIFE - Neuroscience Center, University of Helsinki, Helsinki, Finland
4Department of Computer Science, Aalto University School of Science, Espoo, Finland
5Department of Clinical Pathology, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
6SIB Labs Infrastructure Unit, University of Eastern Finland, Kuopio, Finland
7Neurosurgery of NeuroCenter, Kuopio University Hospital, University of Eastern Finland (UEF), Kuopio, Finland
8Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland
9Department of Neurosurgery, MRC Oulu, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 5.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202003067584
|Publish Date:|| 2020-03-06
In this study, we performed a comprehensive behavioral and anatomical analysis of the Missing in Metastasis (Mtss1/MIM) knockout (KO) mouse brain. We also analyzed the expression of MIM in different brain regions at different ages. MIM is an I-BAR containing membrane curving protein, shown to be involved in dendritic spine initiation and dendritic branching in Purkinje cells in the cerebellum. Behavioral analysis of MIM KO mice revealed defects in both learning and reverse-learning, alterations in anxiety levels and reduced dominant behavior, and confirmed the previously described deficiency in motor coordination and pre-pulse inhibition. Anatomically, we observed enlarged brain ventricles and decreased cortical volume. Although MIM expression was relatively low in hippocampus after early development, hippocampal pyramidal neurons exhibited reduced density of thin and stubby dendritic spines. Learning deficiencies can be connected to all detected anatomical changes. Both behavioral and anatomical findings are typical for schizophrenia mouse models.
Frontiers in molecular neuroscience
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by the Academy of Finland (PH, SA 307735 and FN, SA 309479), Minerva Foundation (PH), Liv och Hälsa Foundation (PH), Kordelin Foundation (IH), and Doctoral Programme Brain and Mind (PK).
© 2019 Minkeviciene, Hlushchenko, Virenque, Lahti, Khanal, Rauramaa, Koistinen, Leinonen, Noe and Hotulainen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.