University of Oulu

Kasper Katisko, Annakaisa Haapasalo, Anne Koivisto, Johanna Krüger, Päivi Hartikainen, Ville Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Anne M. Remes, & Eino Solje. (2018). Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration. Journal of Alzheimer’s Disease, 62(2), 789–794.

Low prevalence of cancer in patients with frontotemporal lobar degeneration

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Author: Katisko, Kasper1; Haapasalo, Annakaisa2,3; Koivisto, Anne1,3;
Organizations: 1Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, Finland
2Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland
3A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
4Medical Research Center, Oulu University Hospital, Oulu, Finland
5Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland
6Neuro Center, Neurosurgery, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.1 MB)
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Language: English
Published: IOS Press, 2018
Publish Date: 2020-03-10


Several studies have reported reduced risk of cancer in patients with Alzheimer’s disease (AD) or Parkinson’s disease. The relationship between cancer and frontotemporal lobar degeneration (FTLD) has not been previously reported. Here, our aim was to evaluate the occurrence of cancer in Finnish FTLD patients with a high proportion of C9ORF72 repeat expansion carriers in comparison to age- and sex-matched group of AD patients and control subjects classified as not cognitively impaired (NCI). The prevalence of cancer was 9.7% in FTLD, 18.7% in AD, and 17.4% in NCI (FTLD versus AD p = 0.012, FTLD versus NCI p = 0.029) groups. No differences were observed between C9ORF72 repeat expansion carriers and non-carriers inside the FTLD group. To our knowledge, this is the first study showing significantly lower prevalence of cancer in FTLD patients compared to patients with AD or NCI subjects. Our data suggest an inverse association between neurodegeneration and cancer and that FTLD-specific mechanisms may underlie the especially strong inverse association observed in this study.

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Series: Journal of Alzheimer's disease
ISSN: 1387-2877
ISSN-E: 1875-8908
ISSN-L: 1387-2877
Volume: 62
Issue: 2
Pages: 789 - 794
DOI: 10.3233/JAD-170854
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: Funding sources for this study: Finnish Brain Foundation, UEF Strategic Neuroscience Funding, VTR grant 5772816 of Kuopio University Hospital. Authors’ disclosures available online (
Copyright information: © 2018 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0).