University of Oulu

Sen, P., Carlsson, C., Virtanen, S., Simell, S., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M., Orešič, M. (2019) Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clinical and Translational Gastroenterology, 10 (5), e00044. doi:10.14309/ctg.0000000000000044

Persistent alterations in plasma lipid profiles before introduction of gluten in the diet associated with progression to celiac disease

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Author: Sen, Partho1; Carlsson, Cecilia2; Virtanen, Suvi3,4,5,6;
Organizations: 1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
2Department of Chemistry, Örebro University, Örebro, Sweden
3Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Helsinki, Finland
4Faculty of Social Sciences/Health, University of Tampere, Tampere, Finland
5Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
6Science Centre, Tampere University Hospital, Tampere, Finland
7Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland
8Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
9Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
10Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
11Clinical Microbiology, Turku University Hospital, Turku, Finland
122Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
13Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland
14Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
15Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
16Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
17Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
18Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, Finland
19School of Medical Sciences, Örebro University, Örebro, Sweden
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202003128101
Language: English
Published: Wolters Kluwer, 2019
Publish Date: 2020-03-12
Description:

Abstract

Objectives: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply lipidomics to elucidate the early events preceding clinical CD in a cohort of Finnish children, followed up in the Type 1 Diabetes Prediction and Prevention study.

Methods: Mass spectrometry–based lipidomics profiling was applied to a longitudinal/prospective series of 233 plasma samples obtained from CD progressors (n = 23) and healthy controls (n = 23), matched for human leukocyte antigen (HLA) risk, sex, and age. The children were followed from birth until diagnosis of clinical CD and subsequent introduction of a gluten-free diet.

Results: Twenty-three children progressed to CD at a mean age of 4.8 years. They showed increased amounts of triacylglycerols (TGs) of low carbon number and double bond count and a decreased level of phosphatidylcholines by age 3 months as compared to controls. These differences were exacerbated with age but were not observed at birth (cord blood). No significant differences were observed in the essential TGs.

Discussion: Our preliminary findings suggest that abnormal lipid metabolism associates with the development of clinical CD and occurs already before the first introduction of gluten to the diet. Moreover, our data suggest that the specific TGs found elevated in CD progressors may be due to a host response to compromised intake of essential lipids in the small intestine, requiring de novo lipogenesis.

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Series: Clinical and translational gastroenterology
ISSN: 2155-384X
ISSN-E: 2155-384X
ISSN-L: 2155-384X
Volume: 10
Article number: e-00044
DOI: 10.14309/ctg.0000000000000044
OADOI: https://oadoi.org/10.14309/ctg.0000000000000044
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
  https://creativecommons.org/licenses/by-nc-nd/4.0/