Persistent alterations in plasma lipid profiles before introduction of gluten in the diet associated with progression to celiac disease |
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Author: | Sen, Partho1; Carlsson, Cecilia2; Virtanen, Suvi3,4,5,6; |
Organizations: |
1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland 2Department of Chemistry, Örebro University, Örebro, Sweden 3Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Helsinki, Finland
4Faculty of Social Sciences/Health, University of Tampere, Tampere, Finland
5Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland 6Science Centre, Tampere University Hospital, Tampere, Finland 7Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland 8Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland 9Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland 10Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland 11Clinical Microbiology, Turku University Hospital, Turku, Finland 122Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland 13Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland 14Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland 15Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden 16Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 17Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland 18Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, Finland 19School of Medical Sciences, Örebro University, Örebro, Sweden |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 1.2 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe202003128101 |
Language: | English |
Published: |
Wolters Kluwer,
2019
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Publish Date: | 2020-03-12 |
Description: |
AbstractObjectives: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply lipidomics to elucidate the early events preceding clinical CD in a cohort of Finnish children, followed up in the Type 1 Diabetes Prediction and Prevention study. Methods: Mass spectrometry–based lipidomics profiling was applied to a longitudinal/prospective series of 233 plasma samples obtained from CD progressors (n = 23) and healthy controls (n = 23), matched for human leukocyte antigen (HLA) risk, sex, and age. The children were followed from birth until diagnosis of clinical CD and subsequent introduction of a gluten-free diet. Results: Twenty-three children progressed to CD at a mean age of 4.8 years. They showed increased amounts of triacylglycerols (TGs) of low carbon number and double bond count and a decreased level of phosphatidylcholines by age 3 months as compared to controls. These differences were exacerbated with age but were not observed at birth (cord blood). No significant differences were observed in the essential TGs. Discussion: Our preliminary findings suggest that abnormal lipid metabolism associates with the development of clinical CD and occurs already before the first introduction of gluten to the diet. Moreover, our data suggest that the specific TGs found elevated in CD progressors may be due to a host response to compromised intake of essential lipids in the small intestine, requiring de novo lipogenesis. see all
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Series: |
Clinical and translational gastroenterology |
ISSN: | 2155-384X |
ISSN-E: | 2155-384X |
ISSN-L: | 2155-384X |
Volume: | 10 |
Article number: | e-00044 |
DOI: | 10.14309/ctg.0000000000000044 |
OADOI: | https://oadoi.org/10.14309/ctg.0000000000000044 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
Subjects: | |
Copyright information: |
© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |