University of Oulu

Sandrine Bretaud, Emilie Guillon, Sanna-Maria Karppinen, Taina Pihlajaniemi, Florence Ruggiero, Collagen XV, a multifaceted multiplexin present across tissues and species, Matrix Biology Plus, Volumes 6–7, 2020, 100023, ISSN 2590-0285,

Collagen XV, a multifaceted multiplexin present across tissues and species

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Author: Bretaud, Sandrine1; Guillon, Emilie1; Karppinen, Sanna-Maria2;
Organizations: 1Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon, UMR CNRS 5242, University of Lyon, Lyon 69364, France
2Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7C, FI-90230 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2020-03-16


Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic properties were subjects of wide interest in the past years. But during the last fifteen years, collagen XV has gained growing attention with increasing number of studies that have attributed new functions to this widely distributed collagen/proteoglycan hybrid molecule. Despite the cumulative evidence of its functional pleiotropy and its evolutionary conserved function, no review compiling the current state of the art about collagen XV is currently available. Here, we thus provide the first comprehensive view of the knowledge gathered so far on the molecular structure, tissue distribution and functions of collagen XV in development, tissue homeostasis and disease with an evolutionary perspective. We hope that our review will open new roads for promising research on collagen XV in the coming years.

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Series: Matrix biology plus
ISSN: 2590-0285
ISSN-E: 2590-0285
ISSN-L: 2590-0285
Volume: 6-7
Article number: 100023
DOI: 10.1016/j.mbplus.2020.100023
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: This work was supported by the AFM-Téléthon (#21064) to FR. The work of S-MK and TP is supported by the Academy of Finland (#308867), the Jane and Aatos Erkko Foundation, and the Sigrid Jusélius Foundation.
Academy of Finland Grant Number: 308867
Detailed Information: 308867 (Academy of Finland Funding decision)
Copyright information: © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (