Liisa Keltikangas-Järvinen, PhD, Kateryna Savelieva, MA, Kim Josefsson, PhD, Marko Elovainio, PhD, Laura Pulkki-Råback, PhD, Markus Juonala, MD, PhD, Olli T. Raitakari, MD, PhD, Mirka Hintsanen, PhD, Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study, Annals of Behavioral Medicine, Volume 51, Issue 4, August 2017, Pages 620–628, https://doi.org/10.1007/s12160-017-9884-2
Accumulation of depressive symptoms and carotid intima-media thickness : the cardiovascular risk in Young Finns Study
|Author:||Keltikangas-Järvinen, Liisa1; Savelieva, Kateryna1; Josefsson, Kim2;|
1Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
2National Institute for Health and Welfare, Helsinki, Finland
3Helsinki Collegium for Advanced Studies, University of Helsinki, Finland
4Department of Medicine, University of Turku, Turku, Finland, Division of Medicine, TurkuUniversity Hospital, Turku, Finland
5Murdoch Childrens Research Institute, Parkville,Victoria, Australia
6Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku,Turku, Finland and Department of Clinical Physiology and Nuclear Medicine, TurkuUniversity Hospital, Turku, Finland
7Unit of Psychology, Faculty of Education, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202003259267
Oxford University Press,
|Publish Date:|| 2020-03-25
Background: The association between depressive symptoms and subclinical atherosclerosis has been inconsistent.
Purpose: We sought to replicate our previous study, which demonstrated a positive relation between depressive symptoms and subclinical atherosclerosis assessed with carotid intima-media thickness (IMT) in men, using a newer measurement of carotid IMT and a cumulative loading of depressive symptoms over three follow-ups.
Methods: The sample comprised 996 adults (352 men) aged 30 to 45 years in 2007 from a prospective population-based Finnish sample. The participants completed a modified version of Beck Depression Inventory in 1992, 1997, and 2001. Carotid IMT was assessed with ultrasound in 2001 and 2007. Cardiovascular risk factors (i.e., body mass index, systolic blood pressure, low-density lipoprotein cholesterol, and smoking) were measured in childhood (1980) and in adulthood (2007).
Results: We found no association between the accumulative depression index and carotid IMT before or after controlling for the traditional risk factors (all p values ≥0.67). Depressive symptoms did not predict IMT progression over two time points and the highest level of carotid wall thickening. Imputed and non-imputed data sets provided similar results. Results remained the same when men and women were analyzed separately. Additional analyses revealed no significant interactions between depressive symptoms and cardiovascular risk factors (i.e., body mass index and systolic blood pressure) on carotid IMT (all p values >0.15).
Conclusions: The findings of this population-based study did not indicate any direct association between depressive symptoms and carotid IMT in asymptomatic, young adults.
Annals of behavioral medicine
|Pages:||620 - 628|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3124 Neurology and psychiatry
3121 General medicine, internal medicine and other clinical medicine
This study was supported by the Signe and Ane Gyllenberg Foundation (MH), the Academy of Finland (258711 (LK-J) and 258578 (MH)), and Research Funds of the University of Helsinki (MH). The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi), and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Sigrid Juselius Foundation, Yrjö Jahnsson Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, the Finnish Cultural Foundation, Tampere Tuberculosis Foundation, The Signe and Ane Gyllenberg Foundation (LP-R) and Emil Aaltonen Foundation.
© 2017, The Society of Behavioral Medicine. This is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Behavioral Medicine following peer review. The version of record Liisa Keltikangas-Järvinen, PhD, Kateryna Savelieva, MA, Kim Josefsson, PhD, Marko Elovainio, PhD, Laura Pulkki-Råback, PhD, Markus Juonala, MD, PhD, Olli T. Raitakari, MD, PhD, Mirka Hintsanen, PhD, Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study, Annals of Behavioral Medicine, Volume 51, Issue 4, August 2017, Pages 620–628 is available online at: https://doi.org/10.1007/s12160-017-9884-2.