University of Oulu

Esteban-Gil, A., Pérez-Sanz, F., García-Solano, J. et al. ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer. Sci Data 6, 255 (2019).

ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer

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Author: Esteban-Gil, Angel1; Pérez-Sanz, Fernando1; García-Solano, José2,3,4;
Organizations: 1Biomedical Informatics & Bioinformatics Platform, Institute for Biomedical Research of Murcia (IMIB)/Foundation for Healthcare Training & Research of the Region of Murcia (FFIS), Calle Luis Fontes Pagán 9, 30003, Murcia, Spain
2Department of Pathology, Santa Lucía General University Hospital (HGUSL), Calle Mezquita sn, 30202, Cartagena, Spain
3Department of Histology and Pathology, Faculty of Life Sciences, Catholic University of Murcia (UCAM), Murcia, Spain
4Research Group on Molecular Pathology and Pharmacogenetics, Institute for Biomedical Research of Murcia (IMIB), Calle Mezquita sn, 30202, Cartagena, Spain
5Departamento de Informática y Sistemas, Universidad de Murcia, IMIB-Arrixaca, 30100, Murcia, Spain
6Department of Oncology, HGUSL, Calle Mezquita sn, 30202, Cartagena, Spain
7Department of Pathology, University of Oulu, Aapistie, 9, 90014, Oulu, Finland
8Central European Institute of Technology, Masaryk University/Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic
9Department of Laboratory Medicine, HGUSL, Cartagena, Spain
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.7 MB)
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Language: English
Published: Springer Nature, 2019
Publish Date: 2020-04-01


Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidence points to a causal role of microbiota and altered microRNA expression in CRC carcinogenesis, but their relationship with pathological drivers or molecular phenotypes is not clearly established. Joint analysis of clinical and omics data can help clarify such relations. We present ColPortal, a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphological manifestation of a complex molecular change. The current cohort consists of Caucasian patients from Europe. For each patient, demographic information, location, histology, tumor staging, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal allows one to perform multiomics analyses for groups of patients selected by their clinical data.

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Series: Scientific data
ISSN: 2052-4463
ISSN-E: 2052-4463
ISSN-L: 2052-4463
Volume: 6
Issue: 1
Article number: 255
DOI: 10.1038/s41597-019-0198-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
113 Computer and information sciences
Copyright information: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit