N. Ashammakhi, S. Ahadian, C. Xu, H. Montazerian, H. Ko, R. Nasiri, N. Barros, A. Khademhosseini, Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs, Materials Today Bio, Volume 1, 2019, 100008, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2019.100008
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
|Author:||Ashammakhi, N.1,2,3; Ahadian, S.1,2; Xu, C.1,2,4;|
1Center for Minimally Invasive Therapeutics (C-MIT), University of California – Los Angeles, Los Angeles, CA, 90095, USA
2Department of Bioengineering, University of California – Los Angeles, Los Angeles, CA, 90095, USA
3Division of Plastic Surgery, Department of Surgery, Oulu University, Oulu, 8000, Finland
4School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia
5Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365-11155, Iran
6Department of Radiological Sciences, University of California – Los Angeles, Los Angeles, CA, 90095, USA
7Department of Chemical and Biomolecular Engineering, University of California – Los Angeles, Los Angeles, CA, 90095, USA
|Online Access:||PDF Full Text (PDF, 4.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020040110051
|Publish Date:|| 2020-04-01
The native tissues are complex structures consisting of different cell types, extracellular matrix materials, and biomolecules. Traditional tissue engineering strategies have not been able to fully reproduce biomimetic and heterogeneous tissue constructs because of the lack of appropriate biomaterials and technologies. However, recently developed three-dimensional bioprinting techniques can be leveraged to produce biomimetic and complex tissue structures. To achieve this, multicomponent bioinks composed of multiple biomaterials (natural, synthetic, or hybrid natural-synthetic biomaterials), different types of cells, and soluble factors have been developed. In addition, advanced bioprinting technologies have enabled us to print multimaterial bioinks with spatial and microscale resolution in a rapid and continuous manner, aiming to reproduce the complex architecture of the native tissues. This review highlights important advances in heterogeneous bioinks and bioprinting technologies to fabricate biomimetic tissue constructs. Opportunities and challenges to further accelerate this research area are also described.
Materials today bio
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
318 Medical biotechnology
The authors acknowledge funding from the National Institutes of Health (AR057837, EB021857-01A1, and AR073135).
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).