Ukkonen, H.; Vuokila, S.; Mikkonen, J.J.W.; Dekker, H.; Schulten, E.A.J.M.; Bloemena, E.; Koistinen, A.; Valdez, T.A.; Kullaa, A.M.; Singh, S.P. Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study. Biosensors 2019, 9, 12. https://doi.org/10.3390/bios9010012
Biochemical changes in irradiated oral mucosa : a FTIR spectroscopic study
|Author:||Ukkonen, Helena1,2,3; Vuokila, Simo3,4; Mikkonen, Jopi J. W.3,4;|
1Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, 90014 Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, 90029 Oulu, Finland
3SIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland
4Institute of Dentistry, University of Eastern Finland, Kuopio campus, and Educational Dental Clinic, Kuopio University Hospital, P.O. Box 1627, 70211 Kuopio, Finland
5Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
6Department of Otolaryngology, School of Medicine, Stanford University, Patlo Alto, CA 94305, USA
|Online Access:||PDF Full Text (PDF, 1.8 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020040110056
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2020-04-01
Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
Finnish Dental Society Apollonia, The Finnish Association of Women Dentists, Orion research foundation, and Medical Research Center Oulu, funds this study to H.U.
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).