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Finnish National Esophago-Gastric Cancer Cohort (FINEGO) for studying outcomes after oesophageal and gastric cancer surgery : a protocol for a retrospective, population-based, nationwide cohort study in Finland |
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| Author: | Kauppila, Joonas H.1,2; Ohtonen, Pasi3; Karttunen, Tuomo J.4; |
| Organizations: |
1Cancer and Translational Medicine Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland 2Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden 3Department of Surgery, Oulu University Hospital, Oulu, Finland
4Department of Pathology, Oulu University Hospital and University of Oulu, Oulu, Finland
5Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 6The Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland 7Department of Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland 8Department of Pathology and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 9Department of General Thoracic and Oesophageal Surgery, Heart and Lung Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 10Department of Surgery, Central Finland Central Hospital, Jyvaskyla, Finland 11Department of Cardiothoracic Surgery, Heart Center, Tampere University Hospital and University of Tampere, Tampere, Tampere, Finland 12Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020040710677 |
| Language: | English |
| Published: |
BMJ,
2019
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| Publish Date: | 2020-04-07 |
| Description: |
AbstractIntroduction: Surgery for oesophageal and gastric cancers is associated with high morbidity, mortality and poor quality of life postoperatively. The Finnish National Esophago-Gastric Cancer Cohort has been established with the aim of identifying factors that could contribute to improved outcomes in oesophago-gastric cancer. Methods and analysis: All patients with oesophageal and gastric cancer diagnosed in Finland between 1987 and 2015 will be identified from the Finnish national registries. The Finnish Cancer Registry and Finnish Patient Registry will be used to identify patients that fulfil the inclusion criteria for the study: (1) diagnosis of oesophageal, gastro-oesophageal junction, or gastric cancer, (2) any surgical treatment for the diagnosed cancer and (3) age of 18 or over at the time of diagnosis. Clinical variables and complication information will be retrieved in extensive data collection from the medical records of the relevant Finnish hospitals and complete follow-up for vital status from Statistics Finland. Primary endpoint is overall all-cause mortality and secondary endpoints include complications, reoperations, medication use and sick leaves. Sub-studies will be implemented within the cohort to investigate specific populations undergoing oesophageal and gastric cancer surgery. The initial estimated sample size is 1800 patients with surgically treated oesophageal cancer and 7500 patients with surgically treated gastric cancer. Ethics and dissemination: The study has been approved by the Ethical Committee in Northern Ostrobothnia, Finland and The National Institute for Health and Welfare, Finland. Study findings will be disseminated via presentations at conferences and publications in peer-reviewed journals. Introduction Surgery for oesophageal and gastric cancers is associated with high morbidity, mortality and poor quality of life postoperatively. The Finnish National Esophago-Gastric Cancer Cohort has been established with the aim of identifying factors that could contribute to improved outcomes in oesophago-gastric cancer. see all
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| Series: |
BMJ open |
| ISSN: | 2044-6055 |
| ISSN-E: | 2044-6055 |
| ISSN-L: | 2044-6055 |
| Volume: | 9 |
| Issue: | 1 |
| Article number: | e024094 |
| DOI: | 10.1136/bmjopen-2018-024094 |
| OADOI: | https://oadoi.org/10.1136/bmjopen-2018-024094 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers 3126 Surgery, anesthesiology, intensive care, radiology |
| Subjects: | |
| Funding: |
This work is supported by research grants from the Sigrid Jusélius Foundation (Sigrid Juséliuksen Säätiö), The Finnish Cancer Foundation (Syöpäsäätiö) and Orion Research Foundation (Orionin Tutkimussäätiö). The funding sources have no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the study protocol for publication. |
| Copyright information: |
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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https://creativecommons.org/licenses/by-nc/4.0/ |