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Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction |
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| Author: | Doaei, Saeid1,2; Kalantari, Naser3; Izadi, Pantea4; |
| Organizations: |
1Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran 2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Department of Internal Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland 6Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran 7Health Promotion and Education Department, Ministry of Health, Tehran, Iran 8Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 9Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Geelong Waurn Ponds, Australia 10Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 11Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020041416465 |
| Language: | English |
| Published: |
Springer Nature,
2019
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| Publish Date: | 2020-04-14 |
| Description: |
AbstractBackground: Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing a lifestyle intervention and the role of FTO genotype in this interaction. Methods: This study was a field trial of 62 adolescents from boys’ high schools in Tehran, Iran. Two schools were randomly allocated as the intervention (n = 30) and control (n = 32) schools. The rs9930506 SNP in FTO was genotyped at baseline and the level of FTO and IRX3 expression in peripheral blood mononuclear cells (PBMCs). Anthropometric measurements were assessed at baseline and after 18 weeks of intensive lifestyle intervention. Results: Our results showed that IRX3 expression in the intervention group was significantly up-regulated compared to baseline (P = 0.007) and compared to the control group (P = 0.011).The intervention group had significantly up-regulated transcripts of IRX3 only in rs9930506 risk allele carriers of the intervention group compared to risk allele carriers of the control group (P = 0.017). Moreover, our data showed that the FTO expression was up-regulated in AA genotype carriers and down-regulated in AG/GG genotype carriers (P = 0.017). Conclusion: Lifestyle modification may exert its effects on obesity through changes in the expression level of the FTO and IRX3 genes. However, FTO genotype plays a role in the extent of the effect of lifestyle changes on gene expression. Further studies are crucial to have a better understanding of the interaction between lifestyle, genetics and anthropometric measurements. see all
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| Series: |
Journal of translational medicine |
| ISSN: | 1479-5876 |
| ISSN-E: | 1479-5876 |
| ISSN-L: | 1479-5876 |
| Volume: | 17 |
| Article number: | 176 |
| DOI: | 10.1186/s12967-019-1921-4 |
| OADOI: | https://oadoi.org/10.1186/s12967-019-1921-4 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
The study was funded by Shahid Beheshti University of Medical Sciences of Tehran, Iran (code 2842). The funding body was not involved in study design, the collection, analysis or interpretation of data, nor in the writing of the manuscript and the decision to submit the manuscript for publication. |
| Copyright information: |
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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https://creativecommons.org/licenses/by/4.0/ |