University of Oulu

Noora Korkalainen, Lea Partanen, Juha Räsänen, Anneli Yliherva, Kaarin Mäkikallio, Fetal hemodynamics and language skills in primary school-aged children with fetal growth restriction: A longitudinal study, Early Human Development, Volume 134, 2019, Pages 34-40, ISSN 0378-3782, https://doi.org/10.1016/j.earlhumdev.2019.05.019

Fetal hemodynamics and language skills in primary school-aged children with fetal growth restriction : a longitudinal study

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Author: Korkalainen, Noora1,2; Partanen, Lea3; Räsänen, Juha4;
Organizations: 1Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland
2PEDEGO Research Unit, University of Oulu, Oulu, Finland
3Child Language Research Center, Logopedics, University of Oulu, Oulu, Finland
4Department of Obstetrics and Gynecology, University Hospital of Helsinki, University of Helsinki, Helsinki, Finland
5Department of Obstetrics and Gynecology, University Hospital of Turku, University of Turku, Turku, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2020041416509
Language: English
Published: Elsevier, 2019
Publish Date: 2020-06-03
Description:

Abstract

Aim: Long-term follow-up studies on children born with fetal growth restriction (FGR) have revealed a specific profile of neurocognitive difficulties, including problems with speech, language and literacy skills. We hypothesized that problems with communication skills, including language use and literacy skills of FGR children at primary school age are associated with prenatal circulatory changes.

Methods: Ultrasonographic assessment of fetoplacental hemodynamics was performed prenatally in 77 fetuses. After a follow-up period of 8–10 years, assessment of reading and spelling skills using standardized tests and the Children‘s Communication Questionnaire (CCC-2) was performed to measure different language skills in 37 FGR children and 31 appropriately grown (AGA) controls, matched for gestational age.

Results: Increased blood flow resistance in the umbilical artery (UA PI > 2 SD) during fetal life showed odds ratios of 3.5–19.1 for poor literacy and communication skills and need for speech and language therapy. Furthermore, FGR children with prenatal cerebral vasodilatation (cerebroplacental ratio (CPR) < −2 SD) had significantly poorer literacy and communication skills, at primary school age compared to the AGA controls. Abnormal CPR demonstrated odds ratios of 4.2–28.1 for poor literacy and communication skills and need for speech and language therapy.

Conclusion: Increased blood flow resistance in the umbilical artery and cerebral vasodilatation are associated with poor communication, language, and literacy skills at early school age in children born with FGR. These findings indicate the need for continuous follow-up of this group and timely targeted support to ensure optimal academic outcomes.

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Series: Early human development
ISSN: 0378-3782
ISSN-E: 1872-6232
ISSN-L: 0378-3782
Volume: 134
Pages: 34 - 40
DOI: 10.1016/j.earlhumdev.2019.05.019
OADOI: https://oadoi.org/10.1016/j.earlhumdev.2019.05.019
Type of Publication: A1 Journal article – refereed
Field of Science: 314 Health sciences
6121 Languages
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Funding: This work was supported by the Alma och K.A. Snellman Foundation (NK), the Instrumentarium Foundation under Grant 180014 (NK); the Finnish Cultural Foundation under Grant 00180555 (NK), Oulu University Health and Biosciences Doctoral Programme (NK) and the Finnish Medical Foundation (KM).
Copyright information: © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/