Chen Y, Li J, Li T, et al. Association between homocysteine, vitamin B₁₂, folic acid and erectile dysfunction: a cross-sectional study in China, BMJ Open 2019;9:e023003. doi: 10.1136/bmjopen-2018-023003
Association between homocysteine, vitamin B₁₂, folic acid and erectile dysfunction : a cross-sectional study in China
|Author:||Chen, Yang1,2,3; Li, Jie2,4; Li, Tianyu1,2,3;|
1Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
2Center for Genomicand Personalized Medicine, Guangxi Medical University, Nanning, China
3Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
4Department of Reproduction, The Guangxi Zhuang Autonomous Region Family Planning Research Center, Nanning, China
5School of Public Health, Guangxi Medical University, Nanning, China
6Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020041618859
|Publish Date:|| 2020-04-16
Objectives: Erectile dysfunction (ED) affects up to 53.4% of men aged 30–80 years. In this study, we aimed to examine the association between homocysteine (HCY), vitamin B₁₂ (B12), folic acid (FA) and ED.
Design: Cross-sectional study.
Setting: Guangxi, China.
Participants: A total of 1381 participants who completed questionnaires were included, between September 2009 and December 2009.
Measures: ED was evaluated by the International Index of Erectile Function scores. Also, the values of HCY, B12 and FA were acquired. Then, regression and between-group analyses were performed.
Results: No association between FA and ED was found. Significant correlations between HCY and ED were found—the relationships between these two parameters were most notable in men aged over 60 years and in men living alone (bachelors or bachelorhood). B12 levels were higher in men with ED (718.53±234.37 pg/mL vs 688.74±229.68, p=0.015). Using multinomial logistic regression analyses, B12 levels were related to mild ED (multivariate adjusted analysis: OR 1.620, 95% CI 1.141 to 2.300, p=0.007), especially among men aged 40–49 years (OR 2.907, 95% CI 1.402 to 6.026, p=0.004).
Conclusions: We report, for the first time, a relationship between B12 levels and ED. We also found specific cohorts of men for whom the relationship between HCY levels and ED is most prominent. Further studies are required to elucidate the mechanisms underlying these relationships—these may ultimately result in new therapies for ED.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This study was funded by National Natural Science Foundation of China (81770759, 81370857), and Innovation Project of Guangxi Graduate Education (YCBZ2017037).
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