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Cord-blood lipidome in progression to islet autoimmunity and type 1 diabetes |
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| Author: | Lamichhane, Santosh1; Ahonen, Linda2; Dyrlund, Thomas Sparholt2; |
| Organizations: |
1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland 2Steno Diabetes Center Copenhagen, 2820 Gentofte, Denmark 3Children’s Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland
4Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland
5Fimlab Laboratories, Pirkanmaa Hospital District, 33014 Tampere, Finland 6Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, 20520 Turku, Finland 7Clinical Microbiology, Turku University Hospital, 20014 Turku, Finland 8Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, 20014 Turku, Finland 9Department of Pediatrics, Turku University Hospital, 20521 Turku, Finland 10Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, 90014 Oulu, Finland 11Department of Children and Adolescents, Oulu University Hospital, 90220 Oulu, Finland 12Department of Women’s and Children’s Health, Karolinska Institutet, 17177 Stockholm, Sweden 13School of Science and Technology, Örebro University, 70281 Örebro, Sweden 14Tampere Center for Child Health Research, Tampere University Hospital, 33520 Tampere, Finland 15Folkhälsan Research Center, 00290 Helsinki, Finland 16School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.7 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020042722590 |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute,
2019
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| Publish Date: | 2020-04-27 |
| Description: |
AbstractPrevious studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR. see all
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| Series: |
Biomolecules |
| ISSN: | 2218-273X |
| ISSN-E: | 2218-273X |
| ISSN-L: | 2218-273X |
| Volume: | 9 |
| Issue: | 1 |
| Article number: | 33 |
| DOI: | 10.3390/biom9010033 |
| OADOI: | https://oadoi.org/10.3390/biom9010033 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
The DIPP study was supported by the JDRF grants 4-1998-274, 4-1999-731 4-2001-435 and special research funds for Oulu, Tampere and Turku University Hospitals in Finland. This work was supported by the Juvenile Diabetes Research Foundation (2-SRA-2014-159-Q-R to M.O.) and the Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research—SyMMyS, Decision No. 250114, to M.O. and M.K.). |
| Copyright information: |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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https://creativecommons.org/licenses/by/4.0/ |