University of Oulu

Uusitalo, U.; Andren Aronsson, C.; Liu, X.; Kurppa, K.; Yang, J.; Liu, E.; Skidmore, J.; Winkler, C.; Rewers, M.J.; Hagopian, W.A.; She, J.-X.; Toppari, J.; Ziegler, A.-G.; Akolkar, B.; Norris, J.M.; Virtanen, S.M.; Krischer, J.P.; Agardh, D.; on behalf of the TEDDY Study Group. Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients 2019, 11, 1790. https://doi.org/10.3390/nu11081790

Early probiotic supplementation and the risk of celiac disease in children at genetic risk

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Author: Uusitalo, Ulla1,2,3,4; Aronsson, Carin Andren2,5,6,7; Liu, Xiang1,4;
Kurppa, Kalle8,9,6,10,11; Yang, Jimin1,2,3,4; Liu, Edwin12,6,13; Skidmore, Jennifer2,14; Winkler, Christiane2,15,16,17,5,3,18,19,20; Rewers, Marian J.21; Hagopian, William A.1,8,9,12,14,15,22,6,23; She, Jin-Xiong1,8,9,22,24; Toppari, Jorma1,9,22,5,6,23,25,26; Ziegler, Anette-G15,16,17; Akolkar, Beena1,8,9,12,14,15,21,22,23; Norris, Jill M.3; Virtanen, Suvi M.2,8,27,10,28,11,29; Krischer, Jeffrey P.1,9,12,21,22,4; Agardh, Daniel2,6,7; Rewers, Marian1,9,12,14,21,22,13; Bautista, Kimberly5,13; Baxter, Judith17,21,5,3,13; Felipe-Morales, Daniel13; Driscoll, Kimberly17,13; Frohnert, Brigitte, I2,23,13; Gallant, Marisa6,13; Gesualdo, Patricia2,14,5,23,3,13; Hoffman, Michelle5,6,23,13; Karban, Rachel5,13; Norris, Jill2,8,5,3,13; Steck, Andrea8,23,13; Waugh, Kathleen14,15,5,3,13; Simell, Olli G.; Adamsson, Annika5,26; Ahonen, Suvi10,11,29; Akerlund, Mari10,11,29; Hekkala, Anne30,31; Holappa, Henna30,31; Hyoty, Heikki14,10,11; Ikonen, Anni30,31; Ilonen, Jorma8,25,32; Jaminki, Sinikka10,11; Jokipuu, Sanna26; Karlsson, Leena26; Kahonen, Miia23,30,31; Knip, Mikael12,10,11; Koivikko, Minna-Liisa30,31; Koreasalo, Mirva2,10,11,29; Kytola, Jarita10,11; Latva-aho, Tiina30,31; Lindfors, Katri6,11; Lonnrot, Maria14,10,11; Mantymaki, Elina26; Mattila, Markus11; Multasuo, Katja30,31; Mykkanenv, Teija30,31; Niininen, Titha2,10,11; Niinisto, Sari10,29; Nyblom, Mia10,11; Oikarinen, Sami10,11; Ollikainen, Paula31; Pohjola, Sirpa31; Rajala, Petra26; Rautanen, Jenna10,29; Riikonen, Anne10,11,29; Romo, Minna26; Ruohonen, Suvi26; Simell, Satu6,25; Sjoberg, Maija5,25; Stenius, Aino5,30,31; Tossavainen, Paivi30,31; Vaha-Makila, Mari26; Vainionpaa, Sini26; Varjonen, Eeva5,25; Veijola, Riitta23,30,31; Viinikangas, Irene30; Schatz, Desmond9,12,15,16,33; Hopkins, Diane5,24; Steed, Leigh5,6,23,3,24; Bryant, Jennifer24; Silvis, Katherine2,24; Haller, Michael23,33; Gardiner, Melissa24; Mclndoe, Richard24; Sharma, Ashok24; Anderson, Stephen W.34; Jacobsen, Laura23,33; Marks, John23,33; Towe, P. D.33; Ziegler, Anette G.1,8,9,22,18,19,20; Bonifacio, Ezio12,35; D'Angelo, Miryam18,19,20; Gavrisan, Anita18,19,20; Gezginci, Cigdem18,19,20; Heublein, Anja18,19,20; Hoffmann, Verena2,18,19,20; Hummel, Sandra2,18,19,20; Keimer, Andrea2,36; Knopff, Annette15,18,19,20; Koch, Charlotte18,19,20; Koletzko, Sibylle6,37; Ramminger, Claudia18,19,20; Roth, Roswith17,18,19,20; Scholz, Marlon17,5,23,18,19,20; Stock, Joanna23,18,19,20; Warncke, Katharina18,19,20; Wendel, Lorena18,19,20; Lernmark, Ake1,8,9,12,14,16,21,22,3,7; Ask, Maria7; Bremer, Jenny7; Cilio, Corrado12,7; Ericson-Hallstrom, Emelie7; Fors, Annika7; Fransson, Lina7; Gard, Thomas7; Bennet, Rasmus7; Hansen, Monika7; Hyberg, Susanne7; Jisser, Hanna7; Johansen, Fredrik7; Jonsdottir, Berglind7; Jovic, Silvija7; Larsson, Helena Elding14,23,7; Lindstrom, Marielle7; Lundgren, Markus23,7; Manson-Martinez, Maria7; Markan, Maria7; Melin, Jessica5,7; Mestan, Zeliha7; Nilsson, Caroline7; Ottosson, Karin7; Rahmati, Kobra7; Ramelius, Anita7; Salami, Falastin7; Sjoberg, Anette7; Sjoberg, Birgitta7; Torn, Carina8,3,7; Wallin, Anne7; Wimar, Asa23,7; Aberg, Sofie7; Killian, Michael14; Crouch, Claire Cowen14,5,23,3; Akramoff, Ashley14; Chavoshi, Masumeh14; Dunson, Kayleen14; Hervey, Rachel14; Lyons, Rachel14; Meyer, Arlene14; Mulenga, Denise14; Radtke, Jared14; Romancik, Matei14; Schmitt, Davey14; Schwabe, Julie14; Zink, Sarah14; Becker, Dorothy38; Franciscus, Margaret38; Smith, Maryellen Dalmagro-Elias38; Daftary, Ashi38; Klein, Mary Beth38; Yates, Chrystal38; Austin-Gonzalez, Sarah4; Avendano, Maryouri4; Baethke, Sandra4; Brown, Rasheedah5,3,4; Burkhardt, Brant12,14,4; Butterworth, Martha2,4; Clasen, Joanna4; Cuthbertson, David4; Eberhard, Christopher4; Fiske, Steven17,4; Garmeson, Jennifer4; Gowda, Veena4; Heyman, Kathleen4; Hsiao, Belinda4; Karges, Christina4; Laras, Francisco Perez4; Lee, Hye-Seung1,2,6,3,4; Li, Qian4; Liu, Shu4; Lynch, Kristian12,14,17,3,4; Maguire, Colleen4; Malloy, Jamie4; McCarthy, Cristina5,3,4; Merrell, Aubrie4; Meulemans, Steven4; Parikh, Hemang8,4; Quigley, Ryan4; Remedios, Cassandra4; Shaffer, Chris4; Smith, Laura17,5,4; Smith, Susan5,3,4; Sulman, Noah4; Tamura, Roy4; Tewey, Dena4; Toth, Michael4; Vehik, Kendra9,12,14,23,3,4; Vijayakandipan, Ponni4; Wood, Keith4; Abbondondolo, Michael4; Ballard, Lori4; Hadley, David4; McLeod, Wendy4; Yu, Liping12,13; Miao, Dongmei13; Bingley, Polly39; Williams, Alistair39; Chandler, Kyla39; Ball, Olivia39; Kelland, Ilana39; Grace, Sian39; Ben Gillard39; Hagopian, William1,8,9,12,14,15,22,6,23; Erlich, Henry40; Mack, Steven J.40; Fear, Anna Lisa40; Ke, Sandra41; Mulholland, Niveen41; Bourcier, Kasia42; Briese, Thomas14,3,43; Johnson, Suzanne Bennett17,5,44; Triplett, Eric14
Organizations: 1Univ S Florida, Morsani Coll Med, Hlth Informat Inst, Dept Pediat, Tampa, FL 33612 USA.
2Lund Univ, Dept Clin Sci, Diabet & Celiac Dis Unit, S-21428 Malmo, Sweden.
3Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO 80045 USA.
4Univ S Florida, Tampa, FL 33612 USA.
5Univ Turku, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku 20014, Finland.
6Turku Univ Hosp, Dept Pediat, Turku 20521, Finland.
7Lund Univ, Lund, Sweden.
8Univ Tampere, Tampere Ctr Child Hlth Res, Tampere 33014, Finland.
9Univ Consortium Seinajoki, Seinajoki 60320, Finland.
10Tampere Univ Hosp, Tampere 33520, Finland.
11Univ Tampere, Tampere, Finland.
12Univ Colorado Denver, Childrens Hosp Colorado, Digest Hlth Inst, Aurora, CO 80045 USA.
13Univ Colorado, Barbara Davis Ctr Childhood Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.
14Pacific Northwest Res Inst, Seattle, WA 98122 USA.
15Helmholtz Zentrum Munchen, Inst Diabet Res, D-85764 Munich, Germany.
16Tech Univ Munich, Klinikum Rechts Isar, Forschergrp Diabet, D-80804 Munich, Germany.
17Helmholtz Zentrum Munchen, Forschergrp Diabet eV, D-85764 Munich, Germany.
18Forschergrp Diabet eV, Munich, Germany.
19Tech Univ Munich, Inst Diabet Res, Helmholtz Zentrum Munchen, Forschergrp Diabet, Munich, Germany.
20Tech Univ Munich, Klinikum Rechts Isar, Munich, Germany.
21Univ Colorado, Barbara Davis Ctr Childhood Diabet, Sch Med, Aurora, CO 80045 USA.
22Augusta Univ, Med Coll Georgia, Augusta, GA 30912 USA.
23NIDDK, NIH, Bethesda, MD 20892 USA.
24Augusta Univ, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA.
25Univ Turku, Turku, Finland.
26Turku Univ Hosp, Hosp Dist Southwest Finland, Turku, Finland.
27Natl Inst Hlth & Welf, Unit Nutr, Helsinki 00271, Finland.
28Pirkanmaa Hosp Dist, Sci Ctr, Tampere 33520, Finland.
29Natl Inst Hlth & Welf, Helsinki, Finland.
30Univ Oulu, Oulu, Finland.
31Oulu Univ Hosp, Oulu, Finland.
32Univ Kuopio, Kuopio, Finland.
33Univ Florida, Gainesville, FL 32611 USA.
34Pediat Endocrine Associates, Atlanta, GA USA.
35Tech Univ Dresden, Ctr Regenerat Therapies, Dresden, Germany.
36Univ Bonn, Dept Nutr Epidemiol, Bonn, Germany.
37Ludwig Maximillians Univ Munich, Dept Gastroenterol, Dr von Hauner Childrens Hosp, Munich, Germany.
38UPMC, Childrens Hosp Pittsburgh, Pittsburgh, PA USA.
39Univ Bristol, Bristol Med Sch, Bristol, Avon, England.
40Childrens Hosp Oakland, Res Inst, Ctr Genet, Oakland, CA 94609 USA.
41NIDDK, Biosample Repository Fisher BioServ, Bethesda, MD 20892 USA.
42NIAID, Rockville, MD USA.
43Columbia Univ, New York, NY 10027 USA.
44Florida State Univ, Tallahassee, FL 32306 USA.
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020042822767
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2020-04-28
Description:

Abstract

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

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Series: Nutrients
ISSN: 2072-6643
ISSN-E: 2072-6643
ISSN-L: 2072-6643
Volume: 11
Issue: 8
Article number: 1790
DOI: 10.3390/nu11081790
OADOI: https://oadoi.org/10.3390/nu11081790
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: his TEDDY Study is funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC), and JDRF. This work supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR001082).
Copyright information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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