University of Oulu

Sirkka, J., Säisänen, L., Julkunen, P. et al. Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study. Fluids Barriers CNS 17, 6 (2020). https://doi.org/10.1186/s12987-020-0167-0

Corticospinal excitability in idiopathic normal pressure hydrocephalus : a transcranial magnetic stimulation study

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Author: Sirkka, Jani1; Säisänen, Laura2,3; Julkunen, Petro2,3;
Organizations: 1Neurocenter, Neurosurgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
2Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
4Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
5Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA
6Unit of Clinical Neuroscience, Neurosurgery, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020050625456
Language: English
Published: Springer Nature, 2020
Publish Date: 2020-05-06
Description:

Abstract

Background: Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition of the motor cortex has been reported in iNPH and can be evaluated in a noninvasive and painless manner using navigated transcranial magnetic stimulation (nTMS). This is the first study to characterize the immediate impact of cerebrospinal fluid (CSF) drainage on corticospinal excitability.

Methods: Twenty patients with possible or probable iNPH (16 women and 4 men, mean age 74.4 years, range 67–84 years), presenting the classical symptom triad and radiological findings, were evaluated with motor function tests (10-m walk test, Grooved Pegboard and Box & Block test) and nTMS (silent period, SP, resting motor threshold, RMT and input–output curve, IO-curve). Evaluations were performed at baseline and repeated immediately after CSF drainage via lumbar puncture.

Results: At baseline, iNPH patients presented shorter SPs (p < 0.001) and lower RMTs (p < 0.001) as compared to normative values. Positive correlation was detected between SP duration and Box & Block test (rho = 0.64, p = 0.002) in iNPH patients. CSF drainage led to an enhancement in gait velocity (p = 0.002) and a steeper IO-curve slope (p = 0.049).

Conclusions: Shorter SPs and lower RMTs in iNPH suggest impaired corticospinal inhibition and corticospinal hyperexcitability. The steeper IO-slope in patients who improve their gait velocity after CSF drainage may indicate a higher recovery potential. Corticospinal excitability correlated with the motor function of the upper limbs implying that the disturbance in motor performance in iNPH extends beyond the classically reported gait impairment.

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Series: Fluids and barriers of the CNS
ISSN: 2045-8118
ISSN-E: 2045-8118
ISSN-L: 2045-8118
Volume: 17
Article number: 6
DOI: 10.1186/s12987-020-0167-0
OADOI: https://oadoi.org/10.1186/s12987-020-0167-0
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: JS has received funding from The Finnish Brain Foundation (Helsinki, Finland), The Maire Taponen Foundation (Espoo, Finland), The Cultural Foundation of Northern Savo (Kuopio, Finland) and The Finnish Medical Foundation (Helsinki, Finland).
Copyright information: © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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