University of Oulu

Michaela Kuhlen, Marina Kunstreich, Riitta Niinimäki, Desiree Dunstheimer, Anita Lawitschka, Edit Bardi, André Willasch, Peter Bader, Wolfgang Högler, Christina Peters, Adriana Balduzzi, Guidance to Bone Morbidity in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplantation, Biology of Blood and Marrow Transplantation, Volume 26, Issue 2, 2020, Pages e27-e37, ISSN 1083-8791,

Guidance to bone morbidity in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation

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Author: Kuhlen, Michaela1,2; Kunstreich, Marina2; Niinimäki, Riitta3;
Organizations: 1University Children's Hospital Augsburg, University Hospital Augsburg, Augsburg, Germany
2Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
3Department of Children and Adolescents, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Pediatrics, Medical University Vienna, St. Anna Children's Hospital, Vienna, Austria
5Department of Pediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria
6University Hospital Frankfurt/Main, Goethe University, Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany
7Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2020-10-13


Allogeneic hematopoietic stem cell transplantation (HSCT) is widely performed in children and adolescents with hematologic diseases, including very high-risk leukemia. With increasing success and survival rates, the long-term sequelae of HSCT have become important. Here, we provide guidance to the prevention and treatment of the most common bone morbidities—osteoporosis and osteonecrosis—emerging in the context of HSCT in children and adolescents. We give an overview on definitions, symptoms, and diagnostics and propose an algorithm for clinical practice based on discussions within the International Berlin Frankfurt Münster (BFM) Stem Cell Transplantation Committee and the Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation, our expert knowledge, and a literature review.

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Series: Biology of blood and marrow transplantation
ISSN: 1083-8791
ISSN-E: 1523-6536
ISSN-L: 1083-8791
Volume: 26
Issue: 2
Pages: e27 - e37
DOI: 10.1016/j.bbmt.2019.10.007
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3123 Gynaecology and paediatrics
Funding: M. Kuhlen is supported by the German Childhood Cancer Foundation (DKS 2011.11).
Copyright information: © 2019. American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license