University of Oulu

Aino Saarinen, Johannes Lieslehto, Vesa Kiviniemi, Timo Tuovinen, Juha Veijola, Mirka Hintsanen, The relationship of genetic susceptibilities for psychosis with physiological fluctuation in functional MRI data, Psychiatry Research: Neuroimaging, Volume 297, 2020, 111031, ISSN 0925-4927,

The relationship of genetic susceptibilities for psychosis with physiological fluctuation in functional MRI data

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Author: Saarinen, Aino1,2,3; Lieslehto, Johannes4,5; Kiviniemi, Vesa6,7;
Organizations: 1Research Unit of Psychology, University of Oulu, Finland
2Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
3Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu
4Section for Neurodiagnostic Applications, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Bavaria, Germany
5Center for Life Course Health Research, University of Oulu, Finland
6Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
7Department of Psychiatry, Oulu University Hospital, Oulu, Finland
8Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2021-01-25


Previously, schizophrenia is found to be related to the variability of the functional magnetic resonance imaging (fMRI) signal in the white matter. However, evidence about the relationship between genetic vulnerabilities and physiological fluctuation in the brain is lacking. We investigated whether familial risk for psychosis (FR) and polygenic risk score for schizophrenia (PRS) are linked with physiological fluctuation in fMRI data. We used data from the Oulu Brain and Mind study (n = 140−149, aged 20−24 years) that is a substudy of the Northern Finland Birth Cohort 1986. The participants underwent a resting-state fMRI scan. Coefficient of variation (CV) of blood oxygen level dependent (BOLD) signal (CVBOLD) was used as a proxy of physiological fluctuation in the brain. Familial risk was defined to be present if at least one parent had been diagnosed with psychosis previously. PRS was computed based on the results of the prior GWAS by the Schizophrenia Working Group. FR or PRS were not associated with CVBOLD in cerebrospinal fluid, white matter, or grey matter. The findings did not provide evidence for the previous suggestions that genetic vulnerabilities for schizophrenia become apparent in alterations of the variation of the BOLD signal in the brain.

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Series: Psychiatry research. Neuroimaging
ISSN: 0925-4927
ISSN-E: 1872-7506
ISSN-L: 0925-4927
Volume: 297
Article number: 111031
DOI: 10.1016/j.pscychresns.2020.111031
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
515 Psychology
3126 Surgery, anesthesiology, intensive care, radiology
Funding: This study was supported financially by the Academy of Finland (J.V., grant number 124257, 141042, 212818, 214273, and 308555; V.K., Terva grant), the Sigrid Juselius Foundation (J.V.), the Gyllenberg Foundation (J.V.), the Medical Research Council (MRC) (V.K.), the Jane and Aatos Erkko Foundation (V.K.), the Finnish Medical Association (J.L.), Yrjö Jahnsson Foundation (J.L.), and Jalmari and Rauha Ahokas Foundation (J.L.). The NFBC study has been financially supported by EU QLG1-CT-2000-01643 (EUROBLCS) grant number E51560, NorFA grant number 731, 20056, 30167, USA / NIHH 2000 G DF682 grant number 50945.
Academy of Finland Grant Number: 124257
Detailed Information: 124257 (Academy of Finland Funding decision)
141042 (Academy of Finland Funding decision)
212818 (Academy of Finland Funding decision)
214273 (Academy of Finland Funding decision)
308555 (Academy of Finland Funding decision)
Copyright information: © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license