University of Oulu

Jyri Järvinen, Jaakko Niinimäki, Jaro Karppinen, Reijo Takalo, Marianne Haapea, Osmo Tervonen, Does bone scintigraphy show Modic changes associated with increased bone turnover?, European Journal of Radiology Open, Volume 7, 2020, 100222, ISSN 2352-0477, https://doi.org/10.1016/j.ejro.2020.100222

Does bone scintigraphy show Modic changes associated with increased bone turnover?

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Author: Järvinen, Jyri1,2,3; Niinimäki, Jaakko1,2,3; Karppinen, Jaro2,4;
Organizations: 1Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
4Finnish Institute of Occupational Health, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020051435471
Language: English
Published: Elsevier, 2020
Publish Date: 2020-05-14
Description:

Abstract

Purpose: Our purpose was to evaluate whether Modic changes (MC) revealed in lumbar MRI are associated with increased tracer uptake shown in bone scintigraphy. To our knowledge, this has not previously been studied.

Methods: We included patients with MC shown in lumbar MRI and bone scintigraphy performed within six months before or after MRI. Exclusion criteria included metastasis and other specific lesions in the area of interest such as discitis, tumors or fractures. We compared the level and type of MC to the degree of tracer uptake shown in bone scintigraphy. Tracer uptake was assessed both visually and quantitatively. We calculated the lesion-to-normal-bone ratios between the MC area with increased tracer uptake and the vertebra with normal tracer uptake. We used linear mixed models in statistical analyses.

Results: Our study sample consisted of 93 patients (aged 37–86) with 299 MC (28 Type 1 (M1), 50 mixed Type 1/2 (M1/2), 3 mixed Type 1/3 (M1/3), 211 Type 2 (M2), 6 mixed Type 2/3 (M2/3), and 1 Type 3 (M3)). Of all the MC, 26 (93 %) M1, 34 (64 %) in the combined M1/2 and M1/3 group, and 11 (5 %) in the combined M2, M2/3 and M3 group showed increased tracer uptake. The mean lesion-to-normal-bone ratio was higher for lesions with a Type 1 component (M1, M1/2 and M1/3) than for other types, at 1.55 (SD 0.16) for M1; 1.44 (SD 0.21) for combined M1/2 and M1/3; and 1.28 (SD 0.11) for combined M2, M2/3 and M3; p = 0.001).

Conclusion: In most cases, MC with a Type 1 component showed increased tracer uptake in bone scintigraphy. This indicates that bone turnover is accelerated in the M1 area.

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Series: European journal of radiology open
ISSN: 2352-0477
ISSN-E: 2352-0477
ISSN-L: 2352-0477
Volume: 7
Article number: 100222
DOI: 10.1016/j.ejro.2020.100222
OADOI: https://oadoi.org/10.1016/j.ejro.2020.100222
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Copyright information: © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/4.0/